2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK9-IN-18

CDK9-IN-18 是一种有效的 CDK9 抑制剂。CDK9-IN-18 阻断激酶 CDK9 的磷酸化功能。CDK9-IN-18 具有良好的抗癌活性和低细胞活性。CDK9-IN-18 可诱导细胞凋亡。

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CDK9-IN-18 Chemical Structure

CDK9-IN-18 Chemical Structure

CAS No. : 1804127-83-0

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CDK9-IN-18 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.

体外研究
(In Vitro)

CDK9-IN-18 (compound 12i) (0-20 μM, 3 hours; NH2 cells) suppress both HIV-1 transcription and the phosphorylation at Serine 2 of the RNAPII CTD in a dose-dependent manner[1].
CDK9-IN-18 (compound 12i) (0-5.0 μM, 24 hours; human tumor cell lines) exerts antiproliferative effect through the induction of apoptosis in HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK9-IN-18 相关抗体:

Western Blot Analysis[1]

Cell Line: NH2 cells
Concentration: 0.1, 0.2, 0.5, 1.0 and 2.0 μM
Incubation Time: 3 hours
Result: P-Ser2 level of RNAPII CTD decreased in a dose-dependent fashion.

Cell Cytotoxicity Assay[1]

Cell Line: A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
Concentration: 2.0 μM
Incubation Time: 24 hours
Result: Inhibited with IC50 values of 0.10, 0.53, 0.07 and 0.10 μM for A375, A549, HepG2 and MCF-7 cells, respectively.

Western Blot Analysis[1]

Cell Line: A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
Concentration: 0.1, 0.2, 0.5, 1.0, 2.0 and 5.0 μM
Incubation Time: 24 hours
Result: The expression level of the specific apoptosisassociated protein (cleaved PARP) increased in a dose-dependent fashion.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 cells
Concentration: 1.0 and 5.0 μM
Incubation Time: 24 hours
Result: The percentage of cells in late apoptosis was recorded as 24.2% and 36.3% at 1.0 and 5.0 μM concentrations, respectively.
分子量

472.50

Formula

C27H20N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK9-IN-18 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-181804127-83-0CDKApoptosisCyclin dependent kinaseCDK9apoptosisanticancerInhibitorinhibitorinhibit

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目录号：
HY-147905
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