Celivarone  (Synonyms: SSR149744C)

Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research^[1].

Celivarone (SSR149744C) 具有 I、II、III 和 IV 类抗心律失常试剂的电生理学和血流动力学特性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在麻醉犬迷走神经诱发的心房颤动 (AF) 中，Celivarone (SSR149744C)（3 和 10 mg/kg IV）可终止所有 7 只犬的 AF，并防止 7 只犬中的 4 只再次诱发^[2] .
在心室水平，Celivarone（0.1-10 mg/kg IV 和 3-90 mg/kg PO）可预防麻醉大鼠再灌注引起的心律失常，并具有剂量效应关系，并且剂量为 30-90 mg/kg , 灌胃给药，可降低清醒大鼠永久结扎左冠状动脉后的早期（0-24 小时）死亡率^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

533.74

C₃₄H₄₇NO₄

401925-43-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Avinash R Khitri, et al. Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter. J Cardiovasc Electrophysiol. 2012 May;23(5):462-72.  [Content Brief]

  [2]. Patrick Gautier, et al. In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias. J Cardiovasc Pharmacol. 2005 Feb;45(2):125-35.  [Content Brief]