2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Centanamycin

Centanamycin  (Synonyms: ML-970; AS-I-145; NSC 716970)

目录号: HY-160129
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摩尔计算器

Centanamycin (ML-970; AS-I-145; NSC 716970) 是一种新型的 DNA 结合剂，在 NCI-60 细胞系筛选中中显示出细胞毒活性，平均 GI50 为 34 nM。

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Centanamycin Chemical Structure

Centanamycin Chemical Structure

CAS No. : 413577-16-9

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Centanamycin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
K562 IC50
0.045 μM
Compound: 11a
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
[PMID: 15916443]
L1210 IC50
0.18 μM
Compound: 11a
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
[PMID: 15916443]
L1210 IC50
55 nM
Compound: 6
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
[PMID: 20579889]
P815 IC50
0.068 μM
Compound: 4, CBI-TMI
Cytotoxicity against mouse P815 cells after 3 days
Cytotoxicity against mouse P815 cells after 3 days
[PMID: 16919946]
P815 IC50
0.068 μM
Compound: 11a
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
[PMID: 15916443]
分子量

453.92

Formula

C24H24ClN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Centanamycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centanamycin413577-16-9ML-970 AS-I-145 NSC 716970ML970ML 970NSC716970NSC 716970NSC-716970Nucleoside Antimetabolite/AnalogNCI-60DNA-binding agentcell cytotoxicInhibitorinhibitorinhibit

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