2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. CH-0793076

CH-0793076  (Synonyms: TP3076)

目录号: HY-107096
产品使用指南

摩尔计算器

CH-0793076 (TP3076)，喜树碱的六环类似物，是 TP300 的活性药物和主要代谢物。CH-0793076 抑制 DNA 拓扑异构酶I (DNA topoisomerase I)，IC50 为 2.3 μM。CH-0793076 对表达 BCRP (乳腺癌耐药蛋白) 的细胞也有活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 CH-0793076 TFA 通常具有更好的水溶性和稳定性。

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CH-0793076 Chemical Structure

CH-0793076 Chemical Structure

CAS No. : 534605-78-2

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CH-0793076 的其他形式现货产品:

Customer Review

Other Forms of CH-0793076:

CH-0793076 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].

IC50 & Target[1]

Topoisomerase I

2.3 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.36 nM
Compound: 7c
Antiproliferative activity against human HCT116 cells after 3 days
Antiproliferative activity against human HCT116 cells after 3 days
[PMID: 19254843]
NCI-H460 IC50
2.3 nM
Compound: 7c
Antiproliferative activity against human NCI-H460 cells after 3 days
Antiproliferative activity against human NCI-H460 cells after 3 days
[PMID: 19254843]
PC-6 IC50
0.18 nM
Compound: 7c
Antiproliferative activity against human PC6 cells carrying pRC after 6 days
Antiproliferative activity against human PC6 cells carrying pRC after 6 days
[PMID: 19254843]
PC-6 IC50
0.35 nM
Compound: 7c
Antiproliferative activity against human PC6 expressing BCRP cells after 6 days
Antiproliferative activity against human PC6 expressing BCRP cells after 6 days
[PMID: 19254843]
QG-56 IC50
2.3 nM
Compound: 7c
Antiproliferative activity against human QG56 cells after 3 days
Antiproliferative activity against human QG56 cells after 3 days
[PMID: 19254843]
体外研究
(In Vitro)

CH0793076 (TP3076) (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CH-0793076 相关抗体:
体内研究
(In Vivo)

TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses), a water-soluble prodrug of CH0793076, shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP (WiDr, HT-29, NCI-H460 and AsPC-1, HCT116, COLO 201, HCT-15, Calu-6 and NCI-N87)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

458.51

Formula

C26H26N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CH-0793076 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CH-0793076534605-78-2TP3076CH0793076CH 0793076TP 3076TP-3076Topoisomerasebreastcancerresistancemetaboliteantiproliferativeanti-cancertoxicitycolorectalInhibitorinhibitorinhibit

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