2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Chlorfortunone A

Chlorfortunone A 是一种新的倍半萜类二聚体，可从 Chloranthus fortunei 的根中分离得到。Chlorfortunone A 能够抑制细胞转化生长因子 (TGF) β 的活性。

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Chlorfortunone A Chemical Structure

Chlorfortunone A Chemical Structure

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Chlorfortunone A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity[1].

体外研究
(In Vitro)

Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorfortunone A 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 10, 20, 40 μM
Incubation Time: 4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
Result: Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.

Immunofluorescence[1]

Cell Line: MDA-MB-231 cells
Concentration: 25 μM
Incubation Time: 48 hours
Result: Significantly downregulated the expression of vimentin.
分子量

490.63

Formula

C31H38O5
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chlorfortunone A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorfortunone ATGF-beta/SmadTransforming growth factor betahexacyclic systemdispiro[4,2,5,2]pentadecane-6,10,14-trien moietyMDA-MB-231sesquiterpenoid dimersChloranthus fortuneinatural compoundInhibitorinhibitorinhibit

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目录号：
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