2. Others Neuronal Signaling GPCR/G Protein
  3. Dopamine Receptor Adrenergic Receptor 5-HT Receptor mAChR Isotope-Labeled Compounds
  4. Clozapine-d3

Clozapine-d3  (Synonyms: 氯氮平-d3; HF 1854-d3)

目录号: HY-14539S3
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Clozapine-d3 (HF 1854-d3) 是氘代标记的 Clozapine。Clozapine (HF 1854) 是用于研究精神分裂症的抗精神病药。Clozapine 对许多神经受体有高度的亲和力，是多巴胺受体的有效拮抗剂，Ki 值为 75 nM。Clozapine 抑制毒蕈碱 M1 受体和血清素 5HT2A 受体，Ki 值分别为 9.5 nM 和 4 nM。Clozapine 也是选择性的毒蕈碱 M4 受体的激动剂 (EC50=11 nM)。

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Clozapine-d<sub>3</sub> Chemical Structure

Clozapine-d3 Chemical Structure

CAS No. : 1215691-72-7

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Other Forms of Clozapine-d3:

Clozapine-d3 相关抗体

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查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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α adrenergic receptor β adrenergic receptor

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

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  • 参考文献

生物活性

Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4][5].

分子量

329.84

Formula

C18H16D3ClN4
CAS 号
非标记 CAS
中文名称

氯氮平-d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Clozapine-d3 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Clozapine-d31215691-72-7HF 1854-d3氯氮平-d3Dopamine ReceptorAdrenergic Receptor5-HT ReceptormAChRIsotope-Labeled CompoundsBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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