2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis
  4. CNDAC hydrochloride

CNDAC hydrochloride 

目录号: HY-16445B 纯度: 99.59%
COA 产品使用指南

摩尔计算器

CNDAC hydrochloride 是可口服试剂 Sapacitabine (HY-16445) 的代谢物，为核苷酸类似物。CNDAC hydrochloride 诱导 DNA 损伤和凋亡 (apoptosis)。

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CNDAC hydrochloride Chemical Structure

CNDAC hydrochloride Chemical Structure

CAS No. : 134665-72-8

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规格 价格 是否有货 数量
1 mg ￥1400
In-stock
5 mg ￥3325
In-stock
10 mg ￥4963
In-stock
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50 mg 现货 询价
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Customer Review

Other Forms of CNDAC hydrochloride:

CNDAC hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].

体外研究
(In Vitro)

CNDAC 有一个独特的作用机制: 进入 DNA 后，它诱导单链断裂 (SSBs)，当细胞经历第二个 S 期时，单链断裂 (SSBs) 转化为双链断裂 (DSBs)[1]。
缺乏 Rad51D 和 XRCC3 可使细胞对 CNDAC (0-1 μM; 24 h) 敏感[1]。
CNDAC (0-100 μM; 3 days) 抑制 HL-60 和 THP-1 细胞的增殖[2]。
CNDAC (0-10 μM; 3-6 days) 诱导 HL-60 和 THP-1 细胞的凋亡[2]。
CNDAC (6 μM; 48 h) 诱导 HCT116 细胞在延迟 S 期后的 G2 期停止细胞周期[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CNDAC hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0-100 μM
Incubation Time: 3 days
Result: Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time: 3, 4, 5, and 6 days
Result: Induced apoptosis in both cells.

Cell Cycle Analysis[3]

Cell Line: HCT116
Concentration: 6 μM
Incubation Time: 48 h
Result: 36 and 36% of cells were arrested in late-S and G2/M phases, respectively.
体内研究
(In Vivo)

CNDAC (20mg/kg; i.p.; daily for 10 days) 显示小鼠抗肿瘤活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 mice, P388 tumor model[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, daily for 10 days
Result: Greatly increased the survival time and survival rate.
分子量

288.69

Formula

C10H13ClN4O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (432.99 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4639 mL 17.3196 mL 34.6392 mL
5 mM 0.6928 mL 3.4639 mL 6.9278 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CNDAC hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4639 mL 17.3196 mL 34.6392 mL 86.5981 mL
5 mM 0.6928 mL 3.4639 mL 6.9278 mL 17.3196 mL
10 mM 0.3464 mL 1.7320 mL 3.4639 mL 8.6598 mL
15 mM 0.2309 mL 1.1546 mL 2.3093 mL 5.7732 mL
20 mM 0.1732 mL 0.8660 mL 1.7320 mL 4.3299 mL
25 mM 0.1386 mL 0.6928 mL 1.3856 mL 3.4639 mL
30 mM 0.1155 mL 0.5773 mL 1.1546 mL 2.8866 mL
40 mM 0.0866 mL 0.4330 mL 0.8660 mL 2.1650 mL
50 mM 0.0693 mL 0.3464 mL 0.6928 mL 1.7320 mL
60 mM 0.0577 mL 0.2887 mL 0.5773 mL 1.4433 mL
80 mM 0.0433 mL 0.2165 mL 0.4330 mL 1.0825 mL
100 mM 0.0346 mL 0.1732 mL 0.3464 mL 0.8660 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNDAC134665-72-8Nucleoside Antimetabolite/AnalogDrug MetaboliteApoptosisDNA/RNA Synthesisacute myelogenous leukemiaAMLCHOHL-60THP-1Inhibitorinhibitorinhibit

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