2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. STING Endogenous Metabolite
  4. Cyclic GMP (Standard)

Cyclic GMP (Standard) 

目录号: HY-113469R 纯度: ≥98%
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Cyclic GMP (Standard)是 Cyclic GMP 的分析标准品。本产品用于研究及分析应用。Cyclic GMP 是内源性第二信使，可触发干扰素的产生以响应胞浆 DNA。Cyclic GMP 可激活干扰素基因刺激因子 (STING)，激活导致产生 I 型干扰素和其他免疫介质的信号级联。Cyclic GMP 和 AMP 的偶联物 Cyclic-GMP-AMP，能够诱导 IRF3 磷酸化和核转位，增强抗病毒免疫应答。Cyclic GMP 还可能激活 PDE 降解 cAMP，抑制心肌细胞钙电流 ICa，调节心肌收缩力。Cyclic GMP 的衍生物 8-Br-cGMP 具有抗血小板的活性，Cyclic GMP 可用于抗病毒免疫及心血管疾病的研究。

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Cyclic GMP (Standard) Chemical Structure

Cyclic GMP (Standard) Chemical Structure

CAS No. : 7665-99-8

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规格 价格 是否有货
5 mg ￥1600
询问价格 & 货期
10 mg ￥2400
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25 mg ￥4350
询问价格 & 货期
50 mg ￥6500
询问价格 & 货期
100 mg ￥9800
询问价格 & 货期

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生物活性

Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.

分子量

345.21

Formula

C10H12N5O7P
CAS 号
结构分类
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Cyclic GMP (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic GMP (Standard)7665-99-8STINGEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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