2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Dihydrofolate reductase (DHFR)
  4. D156844 hydrochloride

D156844 (Compound 11a) hydrochloride 是一种 SMN2 promoter 激活剂，其 EC50 为 4 nM。D156844 hydrochloride 提高 NSC-34 细胞中小鼠 SMN 和严重 I 型脊髓性肌萎缩症 (SMA) 成纤维细胞中人类 SMN2 启动子的 mRNA 表达以及全长人类 SMN 蛋白表达。D156844 hydrochloride 可克服 DHFR 抑制。D156844 hydrochloride 可用于 SMA 研究。

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D156844 hydrochloride

D156844 hydrochloride Chemical Structure

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D156844 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research[1].

分子量

454.37

Formula

C21H26Cl2FN5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D156844 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D156844D 156844D-156844DNA/RNA SynthesisDihydrofolate reductase (DHFR)SMN2 promoterNSC-34 cellsFibroblastsDHFR inhibitionSpinal muscular atrophySMAInhibitorinhibitorinhibit

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D156844 hydrochloride
目录号：
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