2. Immunology/Inflammation
  3. STING
  4. Dazostinag disodium

Dazostinag disodium  (Synonyms: TAK-676)

目录号: HY-148029 纯度: 98.16%
COA 产品使用指南

摩尔计算器

Dazostinag disodium (TAK-676) 是一种干扰素基因刺激因子激动剂 (STING)，触发 STING 信号通路激活和 I 型干扰素激活。Dazostinag disodium 也是一种免疫系统调节剂，具有完全消退和持久记忆的 T 细胞免疫功能。Dazostinag disodium 能够促进持久的干扰素依赖性抗肿瘤免疫反应。

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Dazostinag disodium Chemical Structure

Dazostinag disodium Chemical Structure

CAS No. : 2553413-93-5

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规格 价格 是否有货 数量
100 μg ￥6000
In-stock
500 μg 现货 询价
1 mg 现货 询价
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10 mg   询价  

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Customer Review

Other Forms of Dazostinag disodium:

Dazostinag disodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1].

IC50 & Target

STING, Type I interferons[1]
体外研究
(In Vitro)

Dazostinag disodium (1.1, 3.3, and 10 μM; 2 h) dose-dependently activates the STING-TBK1-IRF3 pathway in THP1-Dual human AML cells and CT26.WT cells, but is critically dependent on STING expression[1].
Dazostinag disodium (0-1 μM; 24 h) exerts in vitro immune cell activation function in mouse BM-derived dendritic cells in a dose-dependent manner[1].
Dazostinag disodium (0-1 μM; 24 h) promotes the activation of dendritic cells (DC), natural killer (NK) cells, and T cells, with activation EC50s of 1.27 μM (MoDC), 0.32 μM (BMDC), 0.271 μM (NK), 0.216 μM (CD8+), 0.249 μM (CD4+) at 24 h, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dazostinag disodium 相关抗体:

Western Blot Analysis[1]

Cell Line: THP1-Dual human AML cells and CT26.WT cells
Concentration: 1.1, 3.3, 10 μM
Incubation Time: 2 hours
Result: Increased pTBK1, pSTING, pIRF3 protein level in a dose-dependent manner.
Not induced the phosphorylation of pTBK1 (S172) or pIRF3 (S396) in the absence of STING expression.
体内研究
(In Vivo)

Dazostinag disodium (0.025-2 mg/kg; i.v.; single dose) is well tolerated, exhibits dose-proportional pharmacokinetics in plasma, and exhibits higher exposure in tumor in mice[1].
Dazostinag disodium (1 mg/kg/d, 2 mg/kg/d; i.v.; 13 d) shows anti-tumor function on BALB/c mice bearing A20 syngeneic tumors/CT26.WT syngeneic tumors mode[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice bearing A20 syngeneic tumors/CT26.WT syngeneic tumors model[1]
Dosage: 1 or 2 mg/kg/day
Administration: Intravenous injection; for 3, 6, 9, 12 day, respectively
Result: Resulted in significant T cell–dependent in vivo antitumor activity.
Induced dose-dependent cytokine responses and increased the activation and proliferation of immune cells within the TME and tumor-associated lymphoid tissue.
Clinical Trial
分子量

754.48

Formula

C21H20F2N8Na2O10P2S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (132.54 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3254 mL 6.6271 mL 13.2542 mL
5 mM 0.2651 mL 1.3254 mL 2.6508 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Dazostinag disodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3254 mL 6.6271 mL 13.2542 mL 33.1354 mL
5 mM 0.2651 mL 1.3254 mL 2.6508 mL 6.6271 mL
10 mM 0.1325 mL 0.6627 mL 1.3254 mL 3.3135 mL
15 mM 0.0884 mL 0.4418 mL 0.8836 mL 2.2090 mL
20 mM 0.0663 mL 0.3314 mL 0.6627 mL 1.6568 mL
25 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3254 mL
30 mM 0.0442 mL 0.2209 mL 0.4418 mL 1.1045 mL
40 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8284 mL
50 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL
60 mM 0.0221 mL 0.1105 mL 0.2209 mL 0.5523 mL
80 mM 0.0166 mL 0.0828 mL 0.1657 mL 0.4142 mL
100 mM 0.0133 mL 0.0663 mL 0.1325 mL 0.3314 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dazostinag disodium2553413-93-5TAK-676TAK676TAK 676STINGStimulator of Interferon GenesTMEM173MITAERISMPYST-cell responsetumor microenvironmentTMEinnate immuneadaptive immunecomplete regressionsdurable memoryT-cell immunityIFN-dependentInhibitorinhibitorinhibit

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