2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. AMPK Mitochondrial Metabolism
  4. DBI-2

DBI-2 是一种靶向线粒体复合物 I 的 AMPK 激活剂。DBI-2 破坏 OXPHOS 过程，并减少线粒体中的 ATP 生成。DBI-2 抑制结直肠癌 (CRC) 细胞的增殖。

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DBI-2 Chemical Structure

DBI-2 Chemical Structure

CAS No. : 2939087-00-8

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DBI-2 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells[1].

体外研究
(In Vitro)

DBI-2 抑制 LS174T 细胞和 HCT116 细胞增殖的 IC50 分别为 1.14 μM 和 0.53 μM[1]。
DBI-2 (3 μM；24 小时) 通过激活 AMPK 并抑制 mTOR 和 Wnt 通路来诱导生长抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBI-2 相关抗体:

Western Blot Analysis[1]

Cell Line: LS174T CRC cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Increased p-AMPK and p-ACC, and decreased p-P70S6K and p-S6, and reduced the expression of Axin2 and c-Myc.
体内研究
(In Vivo)

DBI-2（40 mg/kg；腹腔注射；持续 12 天）可抑制结肠直肠癌 (CRC) 异种移植小鼠模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: RAG1−/− γc− mice injected with S174T cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal administration; for 12 days
Result: Suppressed of tumor growth.
分子量

473.40

Formula

C24H29BrN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DBI-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBI-22939087-00-8DBI2DBI 2AMPKMitochondrial MetabolismAMP-activated protein kinaseAMPK activatormitochondrial complex IOXPHOScolorectal cancerInhibitorinhibitorinhibit

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