2. Apoptosis
  3. Apoptosis
  4. Diselaginellin B

Diselaginellin B (化合物 2) 是从 Selaginella Pulvinata 中分离出的天然产物，对人肝癌细胞具有抗增殖，诱导凋亡 (apoptosis) 和抗转移活性。

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Diselaginellin B Chemical Structure

Diselaginellin B Chemical Structure

CAS No. : 1835299-12-1

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Diselaginellin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells[1].

体外研究
(In Vitro)

Diselaginellin B (2.5-10 μM) 对 SMMC-7721 细胞具有细胞毒性，IC50 为 9.0 μM，通过上调 DLD 并且抑制 COX-1/2 和 NNMT 的表达，浓度依赖的诱导细胞凋亡[1]。
Diselaginellin B (0.5-2 μM) 下调 TSPAN8 和 MAGP2，抑制血管形成，减少癌细胞转移和侵袭[1]。
Diselaginellin B (2.5-5 μM) 在 G1 期阻滞细胞周期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diselaginellin B 相关抗体:

Cell Invasion Assay[1]

Cell Line: SMMC-7721
Concentration: 0.5-2 μM
Incubation Time: 48 h
Result: Reduced the cancer cells migration and invasion in a dose-dependent manner.

Real Time qPCR[1]

Cell Line: SMMC-7721
Concentration: 8 μM
Incubation Time: 3 days
Result: Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2
分子量

1007.09

Formula

C68H46O9
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diselaginellin B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diselaginellin B1835299-12-1ApoptosisSMMC-7721HCCSelaginella PulvinataInhibitorinhibitorinhibit

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