2. Apoptosis Immunology/Inflammation
  3. TNF Receptor IFNAR
  4. EM-163

EM-163 是一种合成的 BB-Loop 模拟物。EM-163 可以通过靶向 MyD88 的 TIR 结构域，缓解炎症并防止中毒性休克导致的死亡。EM-163 可以用于 SEB 中毒的研究 (SEB: 葡萄球菌肠毒素 B)。

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EM-163 Chemical Structure

EM-163 Chemical Structure

CAS No. : 1206480-93-4

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EM-163 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B)[1].
体外研究
(In Vitro)

EM-163 (50-100 μg/mL) 可以靶向 TIR 结构域，能与 TIR 结构域的蛋白结合且可以抑制 TIR-TIR 结构域的相互作用[1]。
EM-163 (10-500 μM; 30 min) 在人类单核细胞 (MNS) 中抑制了 SEB (200 ng/mL) 诱导的 TNF-α、IFN-γ、IL-2 和 IL-1b 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EM-163 相关抗体:
体内研究
(In Vivo)

EM-163 (0.21-0.86 mg/mouse; 腹腔注射; 单剂量) 能够有效抑制促炎细胞因子的释放，延迟或避免葡萄球菌肠毒素 B (SEB) 对 BALB/c 小鼠引起的中毒性休克导致的死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SEB-induced BALB/c mice model [1]
Dosage: 0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse
Administration: Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.
Result: Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.
Delayed mouse death even at high doses of SEB (5 μg).
分子量

849.88

Formula

C44H60IN5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EM-163 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EM-1631206480-93-4EM163EM 163TNF ReceptorIFNARTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorMNCsSEBToxic shockMNSInhibitorinhibitorinhibit

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目录号：
HY-163035
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