2. Anti-infection
  3. Bacterial Antibiotic
  4. Ertapenem disodium

Ertapenem disodium  (Synonyms: MK-0826 disodium)

目录号: HY-A0294A 纯度: 98.21%
COA 产品使用指南

摩尔计算器

Ertapenem (MK-0826) disodium 是一种广谱的长效 β-内酰胺抗生素。Ertapenem disodium 对多种厌氧菌具有广谱抗菌活性，其 MIC 值为 0.12 μg/mL。Ertapenem disodium 可用于皮肤、肺、胃、骨盆和泌尿道的细菌感染相关的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ertapenem disodium Chemical Structure

Ertapenem disodium Chemical Structure

CAS No. : 153832-38-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥230
In-stock
5 mg ￥450
In-stock
10 mg ￥720
In-stock
25 mg ￥1200
In-stock
50 mg ￥1800
In-stock
100 mg ￥2650
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Ertapenem disodium:

Ertapenem disodium 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Ertapenem disodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ertapenem disodium 相关抗体:

Cell Viability Assay[1]

Cell Line: B. fragilis (ATCC 25285), B. thetaiotaomicron (ATCC 29741), and Eubacterium lentum (ATCC 43055)
Concentration: 0-100 μg/mL approximately
Incubation Time: 48 h
Result: Inhibited 99.1% of all isolate with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and 98.8% of the isolates were susceptible among the B. fragilis group.
体内研究
(In Vivo)

Ertapenem disodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg[2].
Ertapenem disodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of <0.25 mg/kg/dose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus thigh tissue infection model (DBA/2 mice)[2]
Dosage: 0.5,1, 2, 5, 10 mg/kg (given at 2, 6, 10, 24, 48, 72, 96, 120 h)
Administration: Subcutaneous injection (0.5 mL after infection)
Result: Displayed > 3 log10 CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.
Maintained the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.
Animal Model: Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)[2]
Dosage: 0-3 mg/kg approximately
Administration: Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result: Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
Animal Model: CD-1 mice, rats[2]
Dosage: 10 mg/kg approximately
Administration: Intraperitoneal injection (pharmacokinetic assay)
Result: Exhibited an AUC0-∞ ranging from 1.8-21.82 μg•hr/mL in tissue in mice following a 10-mg/kg i.p. dose.
Exhibited slow clearance rate with a t1/2β of 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8 of 284.15μg•hr/mL.
Clinical Trial
分子量

519.48

Formula

C22H23N3Na2O7S
CAS 号
性状

固体

颜色

White to off-white

中文名称

厄他培南
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (192.50 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9250 mL 9.6250 mL 19.2500 mL
5 mM 0.3850 mL 1.9250 mL 3.8500 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.21%

COA (197 KB) HNMR (232 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Ertapenem disodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9250 mL 9.6250 mL 19.2500 mL 48.1250 mL
5 mM 0.3850 mL 1.9250 mL 3.8500 mL 9.6250 mL
10 mM 0.1925 mL 0.9625 mL 1.9250 mL 4.8125 mL
15 mM 0.1283 mL 0.6417 mL 1.2833 mL 3.2083 mL
20 mM 0.0963 mL 0.4813 mL 0.9625 mL 2.4063 mL
25 mM 0.0770 mL 0.3850 mL 0.7700 mL 1.9250 mL
30 mM 0.0642 mL 0.3208 mL 0.6417 mL 1.6042 mL
40 mM 0.0481 mL 0.2406 mL 0.4813 mL 1.2031 mL
50 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9625 mL
60 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8021 mL
80 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6016 mL
100 mM 0.0193 mL 0.0963 mL 0.1925 mL 0.4813 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ertapenem disodium153832-38-3MK-0826 disodium厄他培南BacterialAntibioticAnaerobes infectionantibioticanaerobic bacteriaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ertapenem disodium
目录号：
HY-A0294A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z