Flucytosine-¹³C,15N₂  (Synonyms: 5-氟胞嘧啶-¹³C,¹⁵N₂; 5-Fluorocytosine-¹³C,15N₂; NSC 103805-¹³C,15N₂; Ro 2-9915-¹³C,15N₂)

Flucytosine-¹³C,¹⁵N₂ (NSC 103805-¹³C,¹⁵N₂; Ro 2-9915-¹³C,¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Flucytosine (HY-B0139).

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

132.07

C₃¹³CH₄FN¹⁵N₂O

1216616-31-7

2022-85-7

氟胞嘧啶-¹³C,¹⁵N₂；5-氟胞嘧啶-¹³C,¹⁵N₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.  [Content Brief]

  [2]. Vermes A, et al. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000 Aug;46(2):171-9.  [Content Brief]

  [3]. Te Dorsthorst DT, et al. In vitro interaction of flucytosine combined with amphotericin B or fluconazole against thirty-five yeast isolates determined by both the fractional inhibitory concentration index and the response surface approach. Antimicrob Agents Chemother. 2002 Sep;46(9):2982-9.  [Content Brief]