2. Gene
  3. Faah - fatty acid amide hydrolase Gene

Faah - fatty acid amide hydrolase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：脂肪酸酰胺水解酶

种属: Rattus norvegicus

基因 ID: 100911581 | 基因类型: protein coding

关于 Faah

Primary_assembly 5: 129,479,824-129,498,677 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 6 phenotypes. Biased expression in Liver (RPKM 24.3), Brain (RPKM 57.9) and 6 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括酰基甘油脂肪酶活性；水解酶活性，作用于线性酰胺中的碳氮（但不是肽）键；和相同的蛋白质结合活性。参与脂肪酸分解代谢过程；单酰基甘油分解代谢过程；和血管收缩的正调节作用。位于细胞器膜上。该基因的人类直系同源物与肥胖和物质相关疾病有关。与人 FAAH（脂肪酸酰胺水解酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including acylglycerol Lipase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and identical protein binding activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Faah 基因产物(1)

mRNA Protein Name
NM_001369126.1 NP_001356055.1 fatty-acid amide hydrolase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amidase activity IDA
IDA: 通过直接分析推断
12734197 RGD
enables fatty acid amide hydrolase activity IDA
IDA: 通过直接分析推断
9122178 RGD
enables fatty acid amide hydrolase activity IMP
IMP: 通过突变表型推断
17545313 RGD
enables hydrolase activity, acting on ester bonds IDA
IDA: 通过直接分析推断
12734197 RGD
enables identical protein binding IMP
IMP: 通过突变表型推断
17158103 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12459591 RGD
enables lipid binding IDA
IDA: 通过直接分析推断
12734197 RGD
enables monoacylglycerol lipase activity IDA
IDA: 通过直接分析推断
17649977 RGD
enables phospholipid binding IMP
IMP: 通过突变表型推断
17158103 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
27191843 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid catabolic process IDA
IDA: 通过直接分析推断
9122178 RGD
involved in fatty acid metabolic process IMP
IMP: 通过突变表型推断
17545313 RGD
involved in monoacylglycerol catabolic process IDA
IDA: 通过直接分析推断
17649977 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
17245358 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in organelle membrane IDA
IDA: 通过直接分析推断
9122178 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
15233753 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
15233753 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Faah 蛋白结构

Amidase

Amidase: cl18951 (94 - 561)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
蛋白主名 其他名称

fatty-acid amide hydrolase 1

anandamide amidase

anandamide amidohydrolase 1

fatty acid ester hydrolase

oleamide hydrolase 1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1227 Carprofen Inhibitor 99.83% 否
HY-B0182 Carmofur Inhibitor 99.95% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-14376 Redafamdastat Inhibitor 99.89% Phase 2
HY-19636 JNJ-42165279 Inhibitor 99.87% Phase 2
Pre-clinical Phase
生物活性分子 (79)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14595 Biochanin A Inhibitor 99.29% 否
HY-119283 MAGL-IN-5 Inhibitor 99.58% 否
HY-10864 URB-597 Inhibitor 99.15% 否
HY-14380 PF-3845 Inhibitor 99.95% 否
HY-15250 JZL195 Inhibitor 99.75% 否
HY-19740 BIA 10-2474 Inhibitor 99.39% 否
HY-N7062 JNJ-1661010 Inhibitor 99.77% 否
HY-116477 URB937 Inhibitor 99.85% 否
HY-136924 FP-Biotin 99.84% 否
HY-125967 AM 374 Inhibitor ≥97.0% 否
HY-10865 LY2183240 Inhibitor 98.01% 否
HY-N2512 1-Monomyristin Inhibitor ≥98.0% 否
HY-155773 VU534 Inhibitor 98.53% 否
HY-103337 N-Arachidonoylserotonin Inhibitor ≥98.0% 否
HY-103461 FAAH-IN-6 Inhibitor 99.70% 否
HY-103462 TC-F2 Inhibitor 99.75% 否
HY-79511 FAAH-IN-2 Inhibitor 98.21% 否
HY-127023 Eicosapentaenoyl serotonin Inhibitor ≥99.0% 否
HY-N2365 Macamide B Inhibitor 98.64% 否
HY-18081 PF 750 Inhibitor 99.29% 否
HY-123863 SSR411298 Inhibitor 99.75% 否
HY-118158 FAAH/MAGL-IN-4 Inhibitor 99.83% 否
HY-18080 SA 47 Inhibitor ≥99.0% 否
HY-N3033 N-​Benzyllinolenamide Inhibitor 99.70% 否
HY-164495 Sob-AM2 / 否
HY-18544 AA38-3 Inhibitor 99.89% 否
HY-18013 JNJ-40355003 Inhibitor 99.81% 否
HY-10862 FAAH inhibitor 1 Inhibitor 98.91% 否
HY-152254 CB2R/FAAH modulator-3 Inhibitor 99.71% 否
HY-111199 JP83 Inhibitor ≥99.0% 否
HY-W751418 N-Nervonoyl taurine / 否
HY-120961 Oleoyl ethyl amide Inhibitor / 否
HY-122159 MDPD Activator / 否
HY-W728451 URB694 Inhibitor / 否
HY-143263 FAAH/MAGL-IN-1 Inhibitor / 否
HY-152253 CB2R/FAAH modulator-2 Inhibitor / 否
HY-139143 WWL154 Inhibitor / 否
HY-168563 BuChE-IN-15 Inhibitor / 否
HY-103463 SA57 Inhibitor ≥99.0% 否
HY-115004 MM-433593 / 否
HY-146342 FAAH/MAGL-IN-3 Inhibitor / 否
HY-149654 FAAH/cPLA2α-IN-1 Inhibitor / 否
HY-N2428 N-(3-Methoxybenzyl)Palmitamide Inhibitor 99.96% 否
HY-157766 FAAH/TRPV1 blocker-1 Inhibitor / 否
HY-148909 Isopropyl dodec-11-enylfluorophosphonate Inhibitor / 否
HY-147910 Carpro-AM1 Inhibitor / 否
HY-143264 FAAH/MAGL-IN-2 Inhibitor / 否
HY-152251 CB2R/FAAH modulator-1 Inhibitor / 否
HY-B1227S Carprofen-d3 Inhibitor / 否
HY-144738 Dual FAAH/sEH-IN-1 Inhibitor / 否
HY-146341 FAAH-IN-5 Inhibitor / 否
HY-116710 3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone Inhibitor / 否
HY-163733 AKU-005 Inhibitor / 否
HY-12909 MK-4409 Inhibitor / 否
HY-14595R Biochanin A (Standard) Inhibitor / 否
HY-120369 URB532 Inhibitor / 否
HY-B1227S1 Carprofen-13C,d3 / 否
HY-151919 FAAH-IN-7 Inhibitor / 否
HY-121558 JP104 Inhibitor / 否
HY-103338 AM1172 Inhibitor / 否
HY-10867 PF-622 Inhibitor / 否
HY-157132 FAAH-IN-8 Inhibitor / 否
HY-19636A JNJ-42165279 dihydrochloride Inhibitor / 否
HY-124744 ASP 8477 Inhibitor / 否
HY-164506 NRMA-8 Modulator / 否
HY-121090 FAAH-IN-9 Inhibitor / 否
HY-139384 FAAH inhibitor 2 Inhibitor / 否
HY-118210 PHOP Inhibitor / 否
HY-158784 Arachidonoyl m-nitroaniline / 否
HY-77491 FAAH/MAGL-IN-5 Inhibitor 99.17% 否
HY-120650 CAY10435 Inhibitor / 否
HY-103339 VDM11 Inhibitor / 否
HY-10869 OL-135 Inhibitor / 否
HY-120481 JNJ-40413269 Inhibitor / 否
HY-111293 Arachidonamide / 否
HY-161965 MK-3168 (12C) Inhibitor / 否
HY-111389 FAAH-IN-1 Inhibitor 99.93% 否
HY-102054 Acetylhydrolase-IN-1 Inhibitor / 否
HY-U00240 SA72 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Faah NCBI NCBI:2166
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