TSFM - Ts translation elongation factor, mitochondrial Gene

中文名称：Ts 翻译延伸因子，线粒体

种属: Homo sapiens

同用名: EFTS; EFTSMT

基因 ID: 10102 | 基因类型: protein coding

关于 TSFM

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,782,787-57,802,856 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 18.8), kidney (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码线粒体翻译延伸因子。所编码的蛋白质是一种酶，可在线粒体蛋白质翻译的延伸步骤中催化翻译延伸因子 Tu 上鸟嘌呤核苷酸的交换。该基因的突变与联合氧化磷酸化缺陷 3 综合征有关。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 3 月]

This gene encodes a mitochondrial translation elongation factor. The encoded protein is an Enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined Oxidative Phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

TSFM 基因产物(4)

mRNA	Protein	Name
NM_001172695.2	NP_001166166.1	elongation factor Ts, mitochondrial isoform 3 precursor
NM_001172696.2	NP_001166167.1	elongation factor Ts, mitochondrial isoform 1 precursor
NM_001172697.2	NP_001166168.1	elongation factor Ts, mitochondrial isoform 4 precursor
NM_005726.6	NP_005717.3	elongation factor Ts, mitochondrial isoform 2 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25910212	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of mitochondrial translation	IDA IDA: 通过直接分析推断	27677415	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSFM 蛋白结构

UBA

EF_TS

0
100
200
300
325 a.a.

蛋白主名

其他名称

elongation factor Ts, mitochondrial

mitochondrial elongation factor Ts

TSFM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TSFM	P43897	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	TSFM	P43897	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Validated Y2H	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Y2H Array	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Validated Y2H	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Y2H Array	32296183
Intra	TSFM	P43897	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Bait-Prey Pool	25910212
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Array	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Bait-Prey Pool	25910212
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3	COXPD3
Encephalomyopathy, Respiratory Failure, And Lactic Acidosis	Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis
Fatal Mitochondrial Disease Due To Coxpd3	Concentric Cardiomyopathy Hypotonia And Lactic Acidosis
Encephalomyopathy Respiratory Failure And Lactic Acidosis	Encephalomyopathy With Respiratory Failure And Lactic Acidosis
Combined Oxidative Phosphorylation Deficiency, Type 3

Nephrotic Syndrome, Type 21

NPHS21	Nephrotic Syndrome Type 21
Nephrotic Syndrome 21

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Combined Oxidative Phosphorylation Deficiency

Combined Oxidative Phosphorylation Deficiency 39

COXPD39	Combined Oxidative Phosphorylation Defect Type 39
Gfm2-Related Combined Oxidative Phosphorylation Defect

Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1	COXPD1
Early Fatal Progressive Hepatoencephalopathy	Hepatoencephalopathy Due To Coxpd1
Combined Oxidative Phosphorylation Deficiency, Type 1	Hepatoencephalopathy, Early Fatal Progressive
Hepatoencephalopathy Early Fatal Progressive

Combined Oxidative Phosphorylation Deficiency 4

COXPD4	Combined Oxidative Phosphorylation Defect Type 4
Combined Oxidative Phosphorylation Deficiency, Type 4

Nephrotic Syndrome, Type 2

NPHS2	Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive
Srn1	Nephrotic Syndrome Type 2
Steroid-Resistant Autosomal Recessive Nephrotic Syndrome	Nephrotic Syndrome 2
Autosomal Recessive Steroid-Resistant Nephrotic Syndrome	Srn
Nephrotic Syndrome, Type 2, Susceptibility To	Idiopathic Nephrotic Syndrome

Metabolic Acidosis

Myopathy, Lactic Acidosis, And Sideroblastic Anemia

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Endemic Typhus

Murine Typhus	Cat Flea Rickettsiosis
Fleaborne Typhus	Rat-Flea Typhus
Rickettsia Felis Spotted Fever	Shop Typhus
Toulon Typhus	Urban Typhus
Urban Typhus Of Malaya	Flea-Borne Typhus
Endemic Flea-Borne Typhus

Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome	MERRF
Fukuhara Syndrome	Myoclonic Epilepsy Associated With Ragged Red Fibers
Myoencephalopathy Ragged-Red Fiber Disease	Myoclonic Epilepsy - Ragged Red Fibers
Myoclonus Epilepsy And Ragged Red Fibers	Myoclonus With Epilepsy And With Ragged Red Fibers
Myoclonic Epilepsy With Ragged Red Fibers	Myoclonic Epilepsy With Ragged-Red Fibers
Fukuhara Disease	Myoclonus Epilepsy Associated With Ragged-Red Fibres
Myoclonus With Epilepsy With Ragged Red Fibers

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15141	TSFM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TSFM	MGD	MGI:1913649
Rattus norvegicus	TSFM	RGD	RGD:1593058
Macaca mulatta	TSFM	VGNC	VGNC:78660
Bos taurus	TSFM	VGNC	VGNC:36413
Felis catus	TSFM	VGNC	VGNC:66612

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TSFM - Ts translation elongation factor, mitochondrial Gene

关于 TSFM

功能概要

TSFM 基因产物(4)

TSFM 蛋白结构

TSFM 蛋白互作信息

关联疾病

直系同源

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TSFM - Ts translation elongation factor, mitochondrial Gene

关于 TSFM

功能概要

TSFM 基因产物(4)

TSFM 蛋白结构

TSFM 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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