TNK2 - tyrosine kinase non receptor 2 Gene

中文名称：酪氨酸激酶非受体 2

种属: Homo sapiens

同用名: ACK; ACK1; ACK-1; p21cdc42Hs

基因 ID: 10188 | 基因类型: protein coding

关于 TNK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,863,364-195,908,551 (from NCBI)

This gene has 31 transcripts (splice variants), 153 orthologues, 32 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues.

功能概要

该基因编码一种酪氨酸激酶，该激酶以其 GTP 结合形式结合 Cdc42Hs，并抑制 Cdc42Hs 的内在和 GTP 酶激活蛋白 (GAP) 刺激的 GTP 酶活性。这种结合是由 47 个氨基酸的独特序列 C 端到 SH3 结构域介导的。该蛋白质可能参与维持 Cdc42Hs 的 GTP 结合活性形式的调节机制，并且直接与酪氨酸磷酸化信号转导途径相关。已从该基因中鉴定出几种选择性剪接的转录物变体，但仅确定了两种转录物变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 Amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

TNK2 基因产物(24)

mRNA	Protein	Name
NM_001010938.2	NP_001010938.2	activated CDC42 kinase 1 isoform 2
NM_001308046.2	NP_001294975.1	activated CDC42 kinase 1 isoform 3
NM_001382271.1	NP_001369200.1	activated CDC42 kinase 1 isoform 4
NM_001382272.1	NP_001369201.1	activated CDC42 kinase 1 isoform 5
NM_001382273.1	NP_001369202.1	activated CDC42 kinase 1 isoform 6
NM_001382274.1	NP_001369203.1	activated CDC42 kinase 1 isoform 6
NM_001382275.1	NP_001369204.1	activated CDC42 kinase 1 isoform 7
NM_001386164.1	NP_001373093.1	activated CDC42 kinase 1 isoform 8
NM_001387707.1	NP_001374636.1	activated CDC42 kinase 1 isoform 9
NM_001387708.1	NP_001374637.1	activated CDC42 kinase 1 isoform 10
NM_001387709.1	NP_001374638.1	activated CDC42 kinase 1 isoform 8
NM_001387710.1	NP_001374639.1	activated CDC42 kinase 1 isoform 8
NM_001387711.1	NP_001374640.1	activated CDC42 kinase 1 isoform 8
NM_001387712.1	NP_001374641.1	activated CDC42 kinase 1 isoform 8
NM_001387713.1	NP_001374642.1	activated CDC42 kinase 1 isoform 1
NM_001387714.1	NP_001374643.1	activated CDC42 kinase 1 isoform 1
NM_001387715.1	NP_001374644.1	activated CDC42 kinase 1 isoform 11
NM_001387716.1	NP_001374645.1	activated CDC42 kinase 1 isoform 12
NM_001387717.1	NP_001374646.1	activated CDC42 kinase 1 isoform 12
NM_001387718.1	NP_001374647.1	activated CDC42 kinase 1 isoform 12
NM_001387719.1	NP_001374648.1	activated CDC42 kinase 1 isoform 13
NM_001387720.1	NP_001374649.1	activated CDC42 kinase 1 isoform 13
NM_001387721.1	NP_001374650.1	activated CDC42 kinase 1 isoform 13
NM_005781.5	NP_005772.3	activated CDC42 kinase 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables epidermal growth factor receptor binding	IDA IDA: 通过直接分析推断	20086093	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16472662	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10360579	GOA
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: 通过直接分析推断	16257963	GOA
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	18993068	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	23686771	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in phosphorylation	IDA IDA: 通过直接分析推断	20333297	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	10587647	GOA
involved in regulation of clathrin-dependent endocytosis	IDA IDA: 通过直接分析推断	18262180	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Grb2-EGFR complex	IDA IDA: 通过直接分析推断	20086093	GOA
located in clathrin-coated pit	IDA IDA: 通过直接分析推断	21169560	GOA
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	18262180	GOA
located in cytoophidium	IDA IDA: 通过直接分析推断	25223282	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20979614	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20333297	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	20333297	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNK2 蛋白结构

Pkinase_Tyr

SH3_9

GTPase_binding

Inhibitor_Mig-6

0
200
400
600
800
1038 a.a.

蛋白主名

其他名称

activated CDC42 kinase 1

activated Cdc42-associated kinase 1

重组 TNK2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75542	ACK1 Protein, Human (sf9, GST)	Q07912-1 (G110-W476)	≥95%

关联疾病

疾病名称

别名

Infantile-Onset Mesial Temporal Lobe Epilepsy With Severe Cognitive Regression

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15	SCAR15
Salih Ataxia	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 15	Spinocerebellar Ataxia, Autosomal Recessive, 15
Ataxia, Spinocerebellar, Autosomal Recessive, Type 15

Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach

Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia	Atypical Chronic Myeloid Leukaemia
Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative	Acml
Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative
Atypical Cml	Subacute Myeloid Leukemia
Subacute Myelogenous Leukaemia	Subacute Myeloid Leukaemia
Subacute Myelosis	Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission
Subacute Monocytic Leukaemia Without Mention Of Remission	Subacute Monocytic Leukaemia

Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency	IMD46
Cid Due To Tfrc Deficiency	Combined Immunodeficiency Due To Tfrc Deficiency

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15147	XAV-939	Inhibitor	99.91%	否
HY-12438	G007-LK	Inhibitor	99.24%	否
HY-13990	NVP-TNKS656		99.66%	否
HY-16910	WIKI4	Inhibitor	99.93%	否
HY-12975	AZ6102	Inhibitor	99.65%	否
HY-13968	JW 55	Inhibitor	98.95%	否
HY-19351	MN-64	Inhibitor	99.61%	否
HY-U00422	K-756	Inhibitor	99.25%	否
HY-148063	DB0614		98.80%	否
HY-123851	MSC2504877	Inhibitor	98.50%	否
HY-15811	XMD8-87	Inhibitor	98.15%	否
HY-101243	XMD16-5	Inhibitor	98.59%	否
HY-148061	DB1113		99.28%	否
HY-143338	ART-IN-1	Inhibitor	98.91%	否
HY-121719	TIQ-A	Inhibitor	99.65%	否
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	否
HY-147886	PARP1-IN-11	Inhibitor	98.58%	否
HY-148065	FMF-06-098-1		/	否
HY-100847	AZ0108	Inhibitor	/	否
HY-12601	TNKS 22	Inhibitor	/	否
HY-145111	TNK2-IN-1	Inhibitor	/	否
HY-146336	PARP1/2/TNKS1/2-IN-1		/	否
HY-153259	TNKS1/2-IN-2	Inhibitor	/	否
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	否
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	否
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-153332	Tankyrase-IN-5	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TNK2	VGNC	VGNC:66420
Canis familiaris	TNK2	VGNC	VGNC:47680
Bos taurus	TNK2	VGNC	VGNC:36183
Mus musculus	TNK2	MGD	MGI:1858308
Rattus norvegicus	TNK2	RGD	RGD:1305957
Macaca mulatta	TNK2	VGNC	VGNC:79192
Others	TNK2	NCBI

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