NET1 - neuroepithelial cell transforming 1 Gene

中文名称：神经上皮细胞转化 1

种属: Homo sapiens

同用名: NET1A; ARHGEF8

基因 ID: 10276 | 基因类型: protein coding

关于 NET1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,412,557-5,459,056 (from NCBI)

This gene has 6 transcripts (splice variants), 267 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 43.6), small intestine (RPKM 31.5) and 25 other tissues.

功能概要

该基因是 Rho 鸟嘌呤核苷酸交换因子家族的一部分。该家族的成员通过催化 GDP 与 GTP 的交换来激活 Rho 蛋白。该基因编码的蛋白质与细胞核内的 RhoA 相互作用，可能在电离辐射后修复 DNA 损伤中发挥作用。该基因的假基因位于 1、7 和 18 号染色体的长臂上。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2012 年 7 月]

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

NET1 基因产物(2)

mRNA	Protein	Name
NM_001047160.3	NP_001040625.1	neuroepithelial cell-transforming gene 1 protein isoform 1
NM_005863.5	NP_005854.2	neuroepithelial cell-transforming gene 1 protein isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24550280	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to hydrogen peroxide	IDA IDA: 通过直接分析推断	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: 通过直接分析推断	21373644	GOA
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	21373644	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	21373644	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NET1 蛋白结构

RhoGEF

0
100
200
300
400
500
596 a.a.

蛋白主名

其他名称

neuroepithelial cell-transforming gene 1 protein

Rho guanine nucleotide exchange factor (GEF) 8

NET1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NET1	Q7Z628	SCRIB	Homo sapiens	Q14160	Phage Display	24550280

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-131171	3β,5α-Tetrahydronorethisterone		/	否
HY-RS09212	NET1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-172029	3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NET1	VGNC	VGNC:32010
Mus musculus	NET1	MGD	MGI:1927138
Macaca mulatta	NET1	VGNC	VGNC:75176
Felis catus	NET1	VGNC	VGNC:63779
Rattus norvegicus	NET1	RGD	RGD:1305034
Canis familiaris	NET1	VGNC	VGNC:43747

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