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  2. EIF3M - eukaryotic translation initiation factor 3 subunit M Gene

EIF3M - eukaryotic translation initiation factor 3 subunit M Gene

中文名称:真核翻译起始因子 3 亚基 M

种属: Homo sapiens

同用名: B5; GA17; PCID1; TANGO7; hfl-B5

基因 ID: 10480 | 基因类型: protein coding

关于 EIF3M

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,583,831-32,606,264 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白质合成所需的真核翻译起始因子 3 完全 (eIF-3) 的一部分。癌细胞系中存在编码蛋白水平升高的情况。编码蛋白的失活已显示通过阻止 mRNA 与核糖体的结合来干扰疱疹病毒 mRNA 的翻译。该基因的假基因位于 X 染色体上。[RefSeq 提供,2011 年 12 月]

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in Cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

EIF3M 基因产物(2)

mRNA Protein Name
NM_001307929.2 NP_001294858.1 eukaryotic translation initiation factor 3 subunit M isoform 2
NM_006360.6 NP_006351.2 eukaryotic translation initiation factor 3 subunit M isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
contributes to translation initiation factor activity IDA
IDA: 通过直接分析推断
25849773 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of eukaryotic translation initiation factor 3 complex IDA
IDA: 通过直接分析推断
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: 通过物理相互作用推断
17322308 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EIF3M 蛋白结构

PCI

PCI: PCI domain (237 - 335)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 3 subunit M

B5 receptor

EIF3M 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF3M Q7L2H7 TRIML2 Homo sapiens Q8N7C3 32296183
种属内
EIF3M Q7L2H7 EIF3B Homo sapiens P55884 33961781
种属内
EIF3M Q7L2H7 EIF3B Homo sapiens P55884 35271311
种属间
EIF3M Q7L2H7 ORF Human immunodeficiency virus Q9Q2G4 22190034
种属内
EIF3M Q7L2H7 EIF3H Homo sapiens O15372 23623729
种属内
EIF3M Q7L2H7 EIF3H Homo sapiens O15372 35271311
种属内
EIF3M Q7L2H7 EIF3F Homo sapiens O00303 32296183
种属内
EIF3M Q7L2H7 EIF3F Homo sapiens O00303 25416956
种属内
EIF3M Q7L2H7 EIF3F Homo sapiens O00303 25416956
种属内
EIF3M Q7L2H7 EIF3F Homo sapiens O00303 32296183
种属内
EIF3M Q7L2H7 EIF3F Homo sapiens O00303 23623729
种属内
EIF3M Q7L2H7 ABI3 Homo sapiens Q9P2A4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF3M 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71577 EIF3M Protein, Human (His-SUMO) Q7L2H7-1 (S2-T374) ≥95%

关联疾病

疾病名称 别名
Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma

Squamous Cell Carcinoma Of Colon

Squamous Cell Carcinoma Of The Colon

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EIF3M VGNC VGNC:72095
Felis catus EIF3M VGNC VGNC:61787
Rattus norvegicus EIF3M RGD RGD:1565840
Mus musculus EIF3M MGD MGI:1351744
Bos taurus EIF3M VGNC VGNC:28403
Canis familiaris EIF3M VGNC VGNC:40279
Others EIF3M NCBI