HCST - hematopoietic cell signal transducer Gene

中文名称：造血细胞信号转导器

种属: Homo sapiens

同用名: DAP10; KAP10; PIK3AP

关于 HCST

功能概要

该基因编码一个跨膜信号适配器，该适配器在其细胞质结构域中包含一个 YxxM 基序。编码的蛋白质可能与 C 型凝集素样受体 NKG2D 形成免疫识别受体复合物的一部分。作为该受体复合物的一部分，该蛋白可通过其胞质内 YxxM 基序激活磷脂酰肌醇 3-激酶依赖性信号通路。这种受体复合物可能通过激活 NK 和 T 细胞反应在细胞存活和增殖中发挥作用。可变剪接导致编码不同异构体的两个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]