2. Gene
  3. GADD45G - growth arrest and DNA damage inducible gamma Gene

GADD45G - growth arrest and DNA damage inducible gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长停滞和 DNA 损伤诱导伽马

种属: Homo sapiens

同用名: CR6; DDIT2; GRP17; GADD45gamma

基因 ID: 10912 | 基因类型: protein coding

关于 GADD45G

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,605,012-89,606,555 (from NCBI)

This gene has 3 transcripts (splice variants), 343 orthologues and 2 paralogues. Broad expression in liver (RPKM 21.4), placenta (RPKM 16.8) and 22 other tissues.

功能概要

该基因是一组基因的成员，其转录水平在应激生长停滞条件和 DNA 损伤剂处理后增加。由该基因编码的蛋白质通过 MTK1/MEKK4 激酶介导 p38/JNK 通路的激活来响应环境压力。 GADD45G 在胎盘中高度表达。[RefSeq 提供，2008 年 7 月]

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GADD45G 基因产物(1)

mRNA Protein Name
NM_006705.4 NP_006696.1 growth arrest and DNA damage-inducible protein GADD45 gamma
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12052864 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
9827804 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
9827804 GOA
involved in positive regulation of p38MAPK cascade IDA
IDA: 通过直接分析推断
9827804 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9827804 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9827804 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GADD45G 蛋白结构

Ribosomal_L7Ae

Ribosomal_L7Ae: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (25 - 107)

  • 0
  • 100
  • 159 a.a.
蛋白主名 其他名称

growth arrest and DNA damage-inducible protein GADD45 gamma

DDIT-2

重组 GADD45G 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70218 GADD45G/DDIT2 Protein, Human (His) O95257 (M1-E159) ≥95%

关联疾病

疾病名称 别名
Pituitary Adenoma

Adenoma Of The Pituitary Gland

Pituitary Adenomas

Adenoma, Pituitary

Pituitary Gland Adenoma

Pituitary Neoplasms
Retinal Microaneurysm

Microaneurysm
Severe Nonproliferative Diabetic Retinopathy

High Risk Non Proliferative Diabetic Retinopathy

Severe Npdr
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Background Diabetic Retinopathy

Non Proliferative Diabetic Retinopathy

Non-Proliferative Diabetic Retinopathy

Nonproliferative Diabetic Retinopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05231 GADD45G Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GADD45G VGNC VGNC:103268
Bos taurus GADD45G VGNC VGNC:29208
Felis catus GADD45G VGNC VGNC:102932
Canis familiaris GADD45G VGNC VGNC:41071
Rattus norvegicus GADD45G RGD RGD:1311796
Mus musculus GADD45G MGD MGI:1346325
Others GADD45G NCBI
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