2. Gene
  3. TCERG1 - transcription elongation regulator 1 Gene

TCERG1 - transcription elongation regulator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录延伸调节因子 1

种属: Homo sapiens

同用名: Urn1; CA150; TAF2S

基因 ID: 10915 | 基因类型: protein coding

关于 TCERG1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,447,330-146,511,961 (from NCBI)

This gene has 17 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码一种调节转录延伸和 pre-mRNA 剪接的核蛋白。编码的蛋白质通过多个 FF 结构域与 RNA 聚合酶 II 的过度磷酸化 C 末端结构域相互作用，并通过 WW 结构域与前体 mRNA 剪接因子 SF1 相互作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TCERG1 基因产物(16)

mRNA Protein Name
NM_001040006.2 NP_001035095.1 transcription elongation regulator 1 isoform 2
NM_001382548.1 NP_001369477.1 transcription elongation regulator 1 isoform 3
NM_001400077.1 NP_001387006.1 transcription elongation regulator 1 isoform 4
NM_001400082.1 NP_001387011.1 transcription elongation regulator 1 isoform 5
NM_001400083.1 NP_001387012.1 transcription elongation regulator 1 isoform 6
NM_001400084.1 NP_001387013.1 transcription elongation regulator 1 isoform 7
NM_001400085.1 NP_001387014.1 transcription elongation regulator 1 isoform 8
NM_001400092.1 NP_001387021.1 transcription elongation regulator 1 isoform 9
NM_001400093.1 NP_001387022.1 transcription elongation regulator 1 isoform 10
NM_001400094.1 NP_001387023.1 transcription elongation regulator 1 isoform 11
NM_001400095.1 NP_001387024.1 transcription elongation regulator 1 isoform 16
NM_001400096.1 NP_001387025.1 transcription elongation regulator 1 isoform 12
NM_001400097.1 NP_001387026.1 transcription elongation regulator 1 isoform 13
NM_001400098.1 NP_001387027.1 transcription elongation regulator 1 isoform 14
NM_001400099.1 NP_001387028.1 transcription elongation regulator 1 isoform 15
NM_006706.4 NP_006697.2 transcription elongation regulator 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
20956529 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17060612 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15383276 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
20956529 GOA
enables ubiquitin-like protein conjugating enzyme binding IPI
IPI: 通过物理相互作用推断
20215116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA splicing IDA
IDA: 通过直接分析推断
20215116 GOA
involved in mRNA processing IDA
IDA: 通过直接分析推断
20215116 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20956529 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20215116 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCERG1 蛋白结构

WW

WW: WW domain (137 - 162)

WW

WW: WW domain (434 - 460)

FF

FF: FF domain (663 - 709)

FF

FF: FF domain (727 - 776)

FF

FF: FF domain (794 - 843)

FF

FF: FF domain (898 - 949)

FF

FF: FF domain (956 - 1007)

FF

FF: FF domain (1015 - 1074)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1098 a.a.
蛋白主名 其他名称

transcription elongation regulator 1

TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD

TCERG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TCERG1 O14776 HTT Homo sapiens P42858
Y2H
17500595
种属内
TCERG1 O14776 HTT Homo sapiens P42858
Y2H
15383276
种属内
TCERG1 O14776 TCERG1 Homo sapiens O14776
Fluorescence Spectr
17060612
种属内
TCERG1 O14776 TCERG1 Homo sapiens O14776
TEM
17060612
种属内
TCERG1 O14776 TCERG1 Homo sapiens O14776
Solid State NMR
17060612
种属内
TCERG1 O14776 TCERG1 Homo sapiens O14776
Light Scattering
17060612
种属内
TCERG1 O14776 Dlg4 Rattus norvegicus P31016
Peptide Array
20467438
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14297 TCERG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14298 TCERG1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TCERG1 VGNC VGNC:47188
Rattus norvegicus TCERG1 RGD RGD:1311748
Macaca mulatta TCERG1 VGNC VGNC:78389
Bos taurus TCERG1 VGNC VGNC:35685
Felis catus TCERG1 VGNC VGNC:66020
Mus musculus TCERG1 MGD MGI:1926421
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