2. Gene
  3. ERP29 - endoplasmic reticulum protein 29 Gene

ERP29 - endoplasmic reticulum protein 29 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：内质网蛋白 29

种属: Homo sapiens

同用名: ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107

基因 ID: 10961 | 基因类型: protein coding

关于 ERP29

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,013,426-112,023,449 (from NCBI)

This gene has 5 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in bone marrow (RPKM 73.5), prostate (RPKM 67.8) and 25 other tissues.

功能概要

该基因编码一种定位于内质网 (ER) 腔的蛋白质。它是蛋白质二硫化物异构酶 (PDI) 蛋白家族的成员，但缺乏活性硫氧还蛋白基序，表明该蛋白质不具有二硫化物异构酶的功能。典型蛋白二聚化，被认为在 ER 内分泌蛋白的加工过程中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 12 月]

This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

ERP29 基因产物(2)

mRNA Protein Name
NM_001034025.2 NP_001029197.1 endoplasmic reticulum resident protein 29 isoform 2 precursor
NM_006817.4 NP_006808.1 endoplasmic reticulum resident protein 29 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22665516 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
22064321 GOA
involved in negative regulation of protein secretion IDA
IDA: 通过直接分析推断
22064321 GOA
acts upstream of or within positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
22064321 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
22064321 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
22064321 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19995400 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
9738895 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ERP29 蛋白结构

ERp29_N

ERp29_N: ERp29, N-terminal domain (33 - 155)

ERp29

ERp29: Endoplasmic reticulum protein ERp29, C-terminal domain (156 - 252)

  • 0
  • 100
  • 200
  • 261 a.a.
蛋白主名 其他名称

endoplasmic reticulum resident protein 29

endoplasmic reticulum lumenal protein ERp28

ERP29 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ERP29 P30040 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
种属内
ERP29 P30040 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
种属内
ERP29 P30040 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
种属内
ERP29 P30040 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
种属内
ERP29 P30040 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
种属内
ERP29 P30040 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
种属内
ERP29 P30040 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
种属内
ERP29 P30040 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
种属内
ERP29 P30040 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
种属内
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Validated Y2H
32296183
种属内
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Y2H Prey Pooling
32296183
种属内
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Y2H Array
32296183
种属内
ERP29 P30040 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ERP29 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71686 ERP29 Protein, Human (GST) P30040-1 (P40-F251) ≥95%

关联疾病

疾病名称 别名
Pharynx Squamous Cell Carcinoma
Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04514 ERP29 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ERP29 VGNC VGNC:40468
Felis catus ERP29 VGNC VGNC:80440
Bos taurus ERP29 VGNC VGNC:28596
Rattus norvegicus ERP29 RGD RGD:619781
Mus musculus ERP29 MGD MGI:1914647
Others ERP29 NCBI
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