ZWINT - ZW10 interacting kinetochore protein Gene

中文名称：ZW10 相互作用着丝粒蛋白

种属: Homo sapiens

同用名: SIP30; ZWINT1; KNTC2AP; HZwint-1

关于 ZWINT

功能概要

该基因编码的蛋白质明显参与着丝粒功能，但具体作用尚不清楚。它与另一种着丝粒蛋白 ZW10 相互作用，可能调节 ZW10 与着丝粒之间的关联。编码的蛋白质在 ZW10 之前定位到前期动粒，并且它在动粒上仍然可以检测到，直到后期后期。它均匀分布于间期细胞的细胞质中。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]