SCAMP4 - secretory carrier membrane protein 4 Gene

中文名称：分泌型载体膜蛋白 4

种属: Homo sapiens

同用名: SCAMP-4

关于 SCAMP4

功能概要

分泌性载体膜蛋白 (SCAMP) 是广泛分布的整合膜蛋白，与膜运输有关。大多数 SCAMP (例如，SCAMP1；MIM 606911) 具有 N 末端胞质 NPF (arg-pro-phe) 重复序列、4 个中央跨膜区域和一个短的 C 末端胞质尾部。这些 SCAMP 可能在由其 NPF 重复序列介导的内吞作用中发挥作用。其他 SCAMP，例如 SCAMP4，缺乏 NPF 重复序列，因此不太可能在内吞作用中发挥作用 (Fernandez-Chacon 和 Sudhof 总结，2000 [PubMed 11050114]) 。[OMIM 提供，2011 年 2 月]

Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]