2. Gene
  3. SCAMP4 - secretory carrier membrane protein 4 Gene

SCAMP4 - secretory carrier membrane protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：分泌型载体膜蛋白 4

种属: Homo sapiens

同用名: SCAMP-4

基因 ID: 113178 | 基因类型: protein coding

关于 SCAMP4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,905,399-1,926,013 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 16.8), thyroid (RPKM 14.8) and 25 other tissues.

功能概要

分泌性载体膜蛋白 (SCAMP) 是广泛分布的整合膜蛋白，与膜运输有关。大多数 SCAMP (例如，SCAMP1；MIM 606911) 具有 N 末端胞质 NPF (arg-pro-phe) 重复序列、4 个中央跨膜区域和一个短的 C 末端胞质尾部。这些 SCAMP 可能在由其 NPF 重复序列介导的内吞作用中发挥作用。其他 SCAMP，例如 SCAMP4，缺乏 NPF 重复序列，因此不太可能在内吞作用中发挥作用 (Fernandez-Chacon 和 Sudhof 总结，2000 [PubMed 11050114]) 。[OMIM 提供，2011 年 2 月]

Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

SCAMP4 基因产物(3)

mRNA Protein Name
NM_001329539.2 NP_001316468.1 secretory carrier-associated membrane protein 4 isoform 2
NM_001329540.2 NP_001316469.1 secretory carrier-associated membrane protein 4 isoform 3
NM_079834.4 NP_524558.1 secretory carrier-associated membrane protein 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCAMP4 蛋白结构

SCAMP

SCAMP: SCAMP family (4 - 180)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

secretory carrier-associated membrane protein 4

SCAMP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCAMP4 Q969E2 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra SCAMP4 Q969E2 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra SCAMP4 Q969E2 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra SCAMP4 Q969E2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SCAMP4 Q969E2 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra SCAMP4 Q969E2 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra SCAMP4 Q969E2 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra SCAMP4 Q969E2 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra SCAMP4 Q969E2 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra SCAMP4 Q969E2 GRN Homo sapiens P28799-2
Validated Y2H
32814053
Intra SCAMP4 Q969E2 GRN Homo sapiens P28799-2
Y2H Pooling
32814053
Intra SCAMP4 Q969E2 GRN Homo sapiens P28799-2
Y2H Array
32814053
Intra SCAMP4 Q969E2 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra SCAMP4 Q969E2 TMEM147 Homo sapiens Q9BVK8
Y2H Array
32296183
Intra SCAMP4 Q969E2 TMEM147 Homo sapiens Q9BVK8
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra SCAMP4 Q969E2 ABHD6 Homo sapiens Q9BV23
Validated Y2H
32296183
Intra SCAMP4 Q969E2 ABHD6 Homo sapiens Q9BV23
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 ABHD6 Homo sapiens Q9BV23
Y2H Array
32296183
Intra SCAMP4 Q969E2 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra SCAMP4 Q969E2 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra SCAMP4 Q969E2 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SCAMP4 Q969E2 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SCAMP4 Q969E2 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SCAMP4 Q969E2 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra SCAMP4 Q969E2 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra SCAMP4 Q969E2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra SCAMP4 Q969E2 CLDN7 Homo sapiens O95471
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies

Intellectual Disability-Strabismus Syndrome

NEDBGF

Mental Retardation, Autosomal Recessive 36, Formerly

Mrt36, Formerly

Autosomal Recessive Mental Retardation 36

Mrt36

Mental Retardation, Autosomal Recessive, Type 36
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12481 SCAMP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SCAMP4 MGD MGI:1928947
Bos taurus SCAMP4 VGNC VGNC:34318
Macaca mulatta SCAMP4 VGNC VGNC:77135
Felis catus SCAMP4 VGNC VGNC:80712
Canis familiaris SCAMP4 VGNC VGNC:45892
Rattus norvegicus SCAMP4 RGD RGD:68354
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z