Adam17 - a disintegrin and metallopeptidase domain 17 Gene

中文名称：解整合素和金属肽酶结构域 17

种属: Mus musculus

同用名: Tace; CD156b

关于 Adam17

功能概要

该基因编码内切蛋白酶去整合素和金属蛋白酶 (ADAM) 家族的成员，这些内切蛋白酶在各种生物过程中发挥重要作用，包括细胞信号传导、粘附和迁移。编码的前原蛋白经过蛋白水解处理以产生成熟的酶，该酶在称为胞外域脱落的过程中参与膜结合蛋白的蛋白水解释放。缺乏编码蛋白的小鼠在子宫内死亡或无法存活超过一周大。可变剪接导致编码不同亚型的多个转录变体，其中一些可能经历类似的处理。 [RefSeq 提供，2016 年 5 月]

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature Enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]