2. Gene
  3. Agt - angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Gene

Agt - angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AngI; AngII; Aogen; Serpina8

基因 ID: 11606 | 基因类型: protein coding

关于 Agt

功能概要

Enables type 1 Angiotensin Receptor binding activity and type 2 Angiotensin Receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt 基因产物(1)

mRNA Protein Name
NM_007428.4 NP_031454.4 angiotensinogen precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables type 1 angiotensin receptor binding IDA
IDA: 通过直接分析推断
9878677 MGI
enables type 2 angiotensin receptor binding IPI
IPI: 通过物理相互作用推断
9878677 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of MAPK cascade IMP
IMP: 通过突变表型推断
9196031 MGI
acts upstream of or within aldosterone secretion IMP
IMP: 通过突变表型推断
9557921 MGI
involved in aldosterone secretion IMP
IMP: 通过突变表型推断
22550170 MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IDA
IDA: 通过直接分析推断
10425188 MGI
acts upstream of or within astrocyte activation IMP
IMP: 通过突变表型推断
9734405 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within brain renin-angiotensin system IDA
IDA: 通过直接分析推断
9878677 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
12657564 MGI
NOT acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: 通过突变表型推断
9734405 MGI
acts upstream of or within drinking behavior IMP
IMP: 通过突变表型推断
9852267 MGI
acts upstream of or within establishment of blood-nerve barrier IMP
IMP: 通过突变表型推断
9734405 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: 通过突变表型推断
9734405 MGI
acts upstream of or within hormone metabolic process IMP
IMP: 通过突变表型推断
12660889 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11606482 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
9310306 MGI
acts upstream of or within negative regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
9310306 MGI
acts upstream of organ growth IDA
IDA: 通过直接分析推断
16374517 MGI
acts upstream of or within ovarian follicle rupture IMP
IMP: 通过突变表型推断
11384650 MGI
acts upstream of or within peristalsis IMP
IMP: 通过突变表型推断
9788961 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
9196031 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
19404405 MGI
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
19023134 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
34615811 MGI
acts upstream of or within positive regulation of fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
11606482 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
19404405 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
12660889 MGI
acts upstream of or within positive regulation of organ growth IDA
IDA: 通过直接分析推断
16374517 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: 通过突变表型推断
12660889 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
23775122 MGI
acts upstream of or within positive regulation of protein kinase C activity IDA
IDA: 通过直接分析推断
23775122 MGI
acts upstream of or within regulation of apoptotic process IDA
IDA: 通过直接分析推断
19404405 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
9557921 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
16585392 MGI
acts upstream of or within regulation of inflammatory response IDA
IDA: 通过直接分析推断
19404405 MGI
acts upstream of or within regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
19404405 MGI
acts upstream of or within regulation of renal output by angiotensin IMP
IMP: 通过突变表型推断
9507198 MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
IMP: 通过突变表型推断
7989296 MGI
acts upstream of or within renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
11606482 MGI
acts upstream of or within renin-angiotensin regulation of aldosterone production IMP
IMP: 通过突变表型推断
9852267 MGI
acts upstream of or within response to cold IMP
IMP: 通过突变表型推断
12574102 MGI
acts upstream of or within response to salt stress IMP
IMP: 通过突变表型推断
9557921 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
9788961 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
9788961 MGI
acts upstream of or within smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
9788961 MGI
acts upstream of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
9788961 MGI
acts upstream of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8675666 MGI
acts upstream of or within vasopressin secretion IMP
IMP: 通过突变表型推断
9557921 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
7989296 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

angiotensinogen

angiotensin I

angiotensin ll

serpin A8

重组 Agt 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73652 Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) P11859 (D25-V477) ≥95%

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-15298 Grazoprevir Inhibitor 99.99% 否
HY-108764 Mipomersen sodium Inhibitor 97.50% 否
HY-15298A Grazoprevir potassium salt Inhibitor 99.63% 否
HY-15298B Grazoprevir hydrate Inhibitor 99.99% 否
HY-15298C Grazoprevir sodium salt Inhibitor / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-W002585 O6-Benzylguanine 99.84% Phase 3
HY-143230 Custirsen / Phase 3
HY-124191 Ravidasvir hydrochloride Inhibitor / Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99530 Valanafusp alfa 98.42% Phase 2
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150736 ODN 20844 Inhibitor / 否
HY-148413 Aprinocarsen sodium Inhibitor 90.35% 否
HY-150744 ODN 24888 Inhibitor / 否
HY-101663 Ruzasvir Inhibitor / 否
HY-147763 HCV-IN-39 Inhibitor / 否
HY-146126 NS5A-IN-4 Inhibitor / 否
HY-147764 HCV-IN-40 Inhibitor / 否
HY-150215 ODN 105870 Inhibitor / 否
HY-150216 ODN 105871 Inhibitor / 否
HY-150740 ODN 21595 Inhibitor / 否
HY-P0162 HCV-IN-4 Inhibitor / 否
HY-P5939 Angiotensinogen (1-13) (human) / 否
HY-RS00466 AGT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Agt NCBI NCBI:183
Rattus norvegicus Agt NCBI NCBI:24179
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