Agt - angiotensinogen Gene

种属: Rattus norvegicus

同用名: Ang; PAT; ANRT; AngII

基因 ID: 24179 | 基因类型: protein coding

关于 Agt

功能概要

Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt 基因产物(1)

mRNA	Protein	Name
NM_134432.2	NP_602308.1	angiotensinogen precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hormone activity	IDA IDA: 通过直接分析推断	8348686	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	21367774	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	16286564	RGD
involved in angiotensin-mediated drinking behavior	IDA IDA: 通过直接分析推断	21281609	RGD
involved in angiotensin-mediated drinking behavior	IMP IMP: 通过突变表型推断	9622148	RGD
involved in artery smooth muscle contraction	IDA IDA: 通过直接分析推断	21076237	RGD
involved in associative learning	IDA IDA: 通过直接分析推断	15245880	RGD
involved in cell growth involved in cardiac muscle cell development	IDA IDA: 通过直接分析推断	21376054	RGD
involved in cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	12130563	RGD
involved in cellular response to angiotensin	IEP IEP: 通过表达模式推断	24431199	RGD
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	21131638	RGD
involved in female pregnancy	IEP IEP: 通过表达模式推断	17977916	RGD
involved in fibroblast proliferation	IDA IDA: 通过直接分析推断	21419085	RGD
involved in intracellular sodium ion homeostasis	IMP IMP: 通过突变表型推断	16380540	RGD
involved in negative regulation of angiogenesis	IDA IDA: 通过直接分析推断	21281454	RGD
involved in negative regulation of cell growth	IMP IMP: 通过突变表型推断	15951342	RGD
involved in negative regulation of tissue remodeling	IDA IDA: 通过直接分析推断	21167013	RGD
involved in operant conditioning	IDA IDA: 通过直接分析推断	15245880	RGD
involved in positive regulation of L-arginine import across plasma membrane	IDA IDA: 通过直接分析推断	7499219	RGD
involved in positive regulation of L-lysine import across plasma membrane	IDA IDA: 通过直接分析推断	7499219	RGD
involved in positive regulation of blood pressure	IDA IDA: 通过直接分析推断	11897768	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IDA IDA: 通过直接分析推断	24465706	RGD
involved in positive regulation of cardiac muscle hypertrophy	IDA IDA: 通过直接分析推断	8348686	RGD
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	22561449	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	24036592	RGD
involved in positive regulation of extracellular matrix constituent secretion	IDA IDA: 通过直接分析推断	21419085	RGD
involved in positive regulation of fibroblast proliferation	IDA IDA: 通过直接分析推断	8348686	RGD
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: 通过直接分析推断	24184594	RGD
involved in positive regulation of neuron projection development	IMP IMP: 通过突变表型推断	18388195	RGD
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: 通过直接分析推断	17616753	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: 通过直接分析推断	11100981	RGD
involved in positive regulation of superoxide anion generation	IDA IDA: 通过直接分析推断	21376054	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IDA IDA: 通过直接分析推断	24595849	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	24595849	RGD
involved in protein import into nucleus	IDA IDA: 通过直接分析推断	21376054	RGD
involved in regulation of apoptotic process	IDA IDA: 通过直接分析推断	24168260	RGD
involved in regulation of calcium ion transport	IDA IDA: 通过直接分析推断	21423294	RGD
involved in regulation of heart rate	IDA IDA: 通过直接分析推断	11897768	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: 通过突变表型推断	11282364	RGD
involved in regulation of transmission of nerve impulse	IDA IDA: 通过直接分析推断	22198171	RGD
involved in renin-angiotensin regulation of aldosterone production	IDA IDA: 通过直接分析推断	21318332	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	18388195	RGD
involved in response to mechanical stimulus	IEP IEP: 通过表达模式推断	23855625	RGD
involved in response to muscle activity involved in regulation of muscle adaptation	IMP IMP: 通过突变表型推断	8252633	RGD
involved in smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	21292788	RGD
involved in stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	21367774	RGD
involved in uterine smooth muscle contraction	IDA IDA: 通过直接分析推断	21401609	RGD
involved in vasoconstriction	IDA IDA: 通过直接分析推断	20955746	RGD
involved in vasodilation	IDA IDA: 通过直接分析推断	21056585	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	8252633	RGD
NOT located in mitochondrion	IDA IDA: 通过直接分析推断	23959064	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

angiotensinogen

angiotensin II	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
serpin A8

重组 Agt 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73651	Serpin A8/Angiotensinogen Protein, Rat (HEK293, His)	P01015 (D25-V477)	≥95%

目录号	产品名	作用方式	纯度	是否罕见病
HY-15298	Grazoprevir	Inhibitor	99.99%	否
HY-108764	Mipomersen sodium	Inhibitor	97.50%	否
HY-15298A	Grazoprevir potassium salt	Inhibitor	99.63%	否
HY-15298B	Grazoprevir hydrate	Inhibitor	99.99%	否
HY-15298C	Grazoprevir sodium salt	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-W002585	O6-Benzylguanine		99.84%	Phase 3
HY-143230	Custirsen		/	Phase 3
HY-124191	Ravidasvir hydrochloride	Inhibitor	/	Phase 2

目录号	产品名	作用方式	纯度	Phase
HY-P99530	Valanafusp alfa		98.42%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-150736	ODN 20844	Inhibitor	/	否
HY-148413	Aprinocarsen sodium	Inhibitor	90.35%	否
HY-150744	ODN 24888	Inhibitor	/	否
HY-101663	Ruzasvir	Inhibitor	/	否
HY-147763	HCV-IN-39	Inhibitor	/	否
HY-146126	NS5A-IN-4	Inhibitor	/	否
HY-147764	HCV-IN-40	Inhibitor	/	否
HY-150215	ODN 105870	Inhibitor	/	否
HY-150216	ODN 105871	Inhibitor	/	否
HY-150740	ODN 21595	Inhibitor	/	否
HY-P0162	HCV-IN-4	Inhibitor	/	否
HY-P5939	Angiotensinogen (1-13) (human)		/	否
HY-RS00466	AGT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Agt	NCBI	NCBI:183
Mus musculus	Agt	NCBI	NCBI:11606

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Agt - angiotensinogen Gene

关于 Agt

功能概要

Agt 基因产物(1)

重组 Agt 蛋白

直系同源

热门区域

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Agt - angiotensinogen Gene

关于 Agt

功能概要

Agt 基因产物(1)

重组 Agt 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z