2. Gene
  3. Nr0b1 - nuclear receptor subfamily 0, group B, member 1 Gene

Nr0b1 - nuclear receptor subfamily 0, group B, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AHX; Ahc; Ahch; Dax1; DAX-1

基因 ID: 11614 | 基因类型: protein coding

关于 Nr0b1

功能概要

This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]

Nr0b1 基因产物(1)

mRNA Protein Name
NM_007430.5 NP_031456.1 nuclear receptor subfamily 0 group B member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
10848616 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15155786 MGI
NOT enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
27601327 MGI
enables transcription corepressor activity IGI
IGI: 通过遗传相互作用推断
15155786 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
23508100 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Leydig cell differentiation IGI
IGI: 通过遗传相互作用推断
15829514 MGI
acts upstream of or within Leydig cell differentiation IMP
IMP: 通过突变表型推断
11564714 MGI
acts upstream of or within Sertoli cell differentiation IGI
IGI: 通过遗传相互作用推断
15829514 MGI
acts upstream of or within Sertoli cell differentiation IMP
IMP: 通过突变表型推断
11564714 MGI
acts upstream of or within adrenal gland development IGI
IGI: 通过遗传相互作用推断
11796523 MGI
acts upstream of or within endodermal cell differentiation IMP
IMP: 通过突变表型推断
16466956 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
12679814 MGI
acts upstream of or within male sex determination IGI
IGI: 通过遗传相互作用推断
15944188 MGI
acts upstream of or within male sex determination IMP
IMP: 通过突变表型推断
12679814 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15062575 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
23508100 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15155786 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15155786 MGI
acts upstream of or within response to immobilization stress IMP
IMP: 通过突变表型推断
11796523 MGI
acts upstream of or within sex determination IGI
IGI: 通过遗传相互作用推断
9486644 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
9843206 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12610109 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10848616 MGI
located in ribosome IDA
IDA: 通过直接分析推断
10848616 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear receptor subfamily 0 group B member 1

adrenal hypoplasia congenita-like protein

adrenal hypoplasia, congenital homolog

nuclear receptor DAX-1

Nr0b1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Anti Tag CoIP
20362541
种属内
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Pull Down
20362541
种属内
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Anti Tag CoIP
17093407
种属内
Nr0b1 Q61066 Nanog Mus musculus Q80Z64
Anti Tag CoIP
17093407
种属内
Nr0b1 Q61066 Rif1 Mus musculus Q6PR54
Anti Tag CoIP
20362541
种属内
Nr0b1 Q61066 Rif1 Mus musculus Q6PR54
Anti Tag CoIP
17093407
种属内
Nr0b1 Q61066 Esrrb Mus musculus Q61539
Anti Tag CoIP
20362541
种属内
Nr0b1 Q61066 Esrrb Mus musculus Q61539
Pull Down
20362541
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% 否
HY-122054 BPK-29 Inhibitor 99.4% 否
HY-RS09525 NR0B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr0b1 NCBI NCBI:190
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