Pou5f1 - POU domain, class 5, transcription factor 1 Gene

中文名称：POU 域，第 5 类，转录因子 1

种属: Mus musculus

同用名: Oct3; Oct4; Otf3; Otf4; NF-A3; Oct-3; Oct-4; Otf-3; Otf-4; Otf3g; Oct3/4; Oct-3/4; Otf3-rs7

基因 ID: 18999 | 基因类型: protein coding

关于 Pou5f1

Chromosome 17: 35,816,915-35,821,669 forward strand.GRCm39:CM001010.3

This gene has 6 transcripts (splice variants), 331 orthologues, 16 paralogues and is associated with 4 phenotypes. Biased expression in testis adult (RPKM 4.) and ovary adult (RPKM 1.5).

功能概要

该基因编码的蛋白质属于转录因子的 POU 结构域家族。 POU 域转录因子与特定八聚体 DNA 基序结合并调节细胞类型特异性分化途径。编码的蛋白质在胚胎发育和干细胞多能性中起着关键作用。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Pou5f1 基因产物(2)

mRNA	Protein	Name
NM_013633.3	NP_038661.2	POU domain, class 5, transcription factor 1 isoform 1
NM_001252452.1	NP_001239381.1	POU domain, class 5, transcription factor 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	1967980	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12615074	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	1967980	MGI
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	23376973	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15047715	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	29153991	MGI
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17541407	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12615074	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: 通过遗传相互作用推断	15863505	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17938240	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	18662995	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	24268575	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15988017	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23495099	MGI
enables cytokine binding	IDA IDA: 通过直接分析推断	23495099	MGI
enables lysine-acetylated histone binding	IDA IDA: 通过直接分析推断	23798425	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	7590241	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	1690859	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	17541407	MGI
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	15047715	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in blastocyst development	IEP IEP: 通过表达模式推断	21258368	MGI
acts upstream of or within blastocyst growth	IGI IGI: 通过遗传相互作用推断	24036311	MGI
acts upstream of or within cell fate commitment	IMP IMP: 通过突变表型推断	9814708	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: 通过表达模式推断	20439489	MGI
acts upstream of or within ectodermal cell fate commitment	IDA IDA: 通过直接分析推断	10742100	MGI
acts upstream of or within endodermal cell fate commitment	IDA IDA: 通过直接分析推断	10742100	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	17267691	MGI
acts upstream of or within germ-line stem cell population maintenance	IMP IMP: 通过突变表型推断	15486564	MGI
acts upstream of or within mesodermal cell fate commitment	IDA IDA: 通过直接分析推断	10742100	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	1967980	MGI
acts upstream of or within negative regulation of calcium ion-dependent exocytosis	IDA IDA: 通过直接分析推断	2357966	MGI
acts upstream of or within negative regulation of cell differentiation	IGI IGI: 通过遗传相互作用推断	16325584	MGI
involved in negative regulation of gene expression	IDA IDA: 通过直接分析推断	23495099	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	16325584	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	1967980	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: 通过直接分析推断	17938240	MGI
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	23495099	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	1972777	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12615074	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	7590241	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15988017	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23376973	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: 通过直接分析推断	26691508	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12665572	MGI
involved in regulation of asymmetric cell division	IEP IEP: 通过表达模式推断	21258368	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15047715	MGI
acts upstream of or within response to retinoic acid	IDA IDA: 通过直接分析推断	18400104	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	9814708	MGI
acts upstream of or within stem cell differentiation	IDA IDA: 通过直接分析推断	20123909	MGI
involved in stem cell differentiation	IMP IMP: 通过突变表型推断	23376973	MGI
involved in stem cell population maintenance	IMP IMP: 通过突变表型推断	23376973	MGI
acts upstream of or within transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	1967980	MGI
acts upstream of trophectodermal cell differentiation	IGI IGI: 通过遗传相互作用推断	16325584	MGI
acts upstream of or within trophectodermal cell differentiation	IGI IGI: 通过遗传相互作用推断	16325584	MGI
acts upstream of or within trophectodermal cell fate commitment	IDA IDA: 通过直接分析推断	10742100	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in chromatin	IDA IDA: 通过直接分析推断	23798425	MGI
located in chromatin	IDA IDA: 通过直接分析推断	23495099	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	7958450	MGI
located in cytoplasm	IMP IMP: 通过突变表型推断	29153991	MGI
located in female germ cell nucleus	IDA IDA: 通过直接分析推断	7958450	MGI
located in germ cell nucleus	IDA IDA: 通过直接分析推断	12641567	MGI
located in male germ cell nucleus	IDA IDA: 通过直接分析推断	9507072	MGI
located in nucleolus	IDA IDA: 通过直接分析推断	19480014	MGI
located in nucleoplasm	IDA IDA: 通过直接分析推断	21076177	MGI
is active in nucleus	IDA IDA: 通过直接分析推断	23798425	MGI
located in nucleus	IDA IDA: 通过直接分析推断	7958450	MGI
located in nucleus	IMP IMP: 通过突变表型推断	23376973	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	7969117	MGI
part of transcription repressor complex	IDA IDA: 通过直接分析推断	16325584	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pou5f1 蛋白结构

POU

Homeobox

0
100
200
300
352 a.a.

蛋白主名

其他名称

POU domain, class 5, transcription factor 1

octamer-binding protein 3	octamer-binding protein 4
octamer-binding transcription factor 3	octamer-binding transcription factor 4 alternative

Pou5f1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Pou5f1	P20263	Wdr5	Mus musculus	P61965	Anti Tag CoIP	20362541
种属内	Pou5f1	P20263	Wdr5	Mus musculus	P61965	Anti Bait CoIP	20362541
种属内	Pou5f1	P20263	Wdr5	Mus musculus	P61965	Anti Tag CoIP	21477851
种属内	Pou5f1	P20263	Wdr5	Mus musculus	P61965	Anti Bait CoIP	21477851
种属内	Pou5f1	P20263	Ewsr1	Mus musculus	Q61545	Pull Down	15917470
种属内	Pou5f1	P20263	Ewsr1	Mus musculus	Q61545	Y2H	15917470
种属内	Pou5f1	P20263	Ewsr1	Mus musculus	Q61545	Anti Bait CoIP	15917470
种属内	Pou5f1	P20263	Nanog	Mus musculus	Q80Z64	Pull Down	17093407
种属内	Pou5f1	P20263	Nanog	Mus musculus	Q80Z64	Anti Tag CoIP	17093407
种属内	Pou5f1	P20263	Nr0b1	Mus musculus	Q61066	Anti Tag CoIP	20362541
种属内	Pou5f1	P20263	Sox2	Mus musculus	P48432	Pull Down	23108051
种属内	Pou5f1	P20263	Sox2	Mus musculus	P48432	Anti Tag CoIP	20362541
种属内	Pou5f1	P20263	Parp1	Mus musculus	P11103	TAP	20362542
种属内	Pou5f1	P20263	Pkm	Mus musculus	P52480	Anti Tag CoIP	18191611
种属内	Pou5f1	P20263	Cdk1	Mus musculus	P11440	Pull Down	23108051
种属内	Pou5f1	P20263	Mta2	Mus musculus	Q9R190	TAP	20362542
种属内	Pou5f1	P20263	Mta2	Mus musculus	Q9R190	Anti Tag CoIP	20362541
种属内	Pou5f1	P20263	Mta2	Mus musculus	Q9R190	Anti Bait CoIP	20362541

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10907	POU5F1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10908	Pou5f1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10909	Pou5f1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10910	POU5F1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Pou5f1	NCBI	NCBI:5460

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pou5f1 - POU domain, class 5, transcription factor 1 Gene

关于 Pou5f1

功能概要

Pou5f1 基因产物(2)

Pou5f1 蛋白结构

Pou5f1 蛋白互作信息

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Pou5f1 - POU domain, class 5, transcription factor 1 Gene

关于 Pou5f1

功能概要

Pou5f1 基因产物(2)

Pou5f1 蛋白结构

Pou5f1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z