Nanog - Nanog homeobox Gene

种属: Mus musculus

同用名: ENK; Stm1; ecat4; 2410002E02Rik

基因 ID: 71950 | 基因类型: protein coding

关于 Nanog

功能概要

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nanog 基因产物(4)

mRNA	Protein	Name
NM_001289828.1	NP_001276757.1	homeobox protein NANOG isoform 2
NM_001289830.1	NP_001276759.1	homeobox protein NANOG isoform 3
NM_001289831.1	NP_001276760.1	homeobox protein NANOG isoform 3
NM_028016.3	NP_082292.1	homeobox protein NANOG isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	12787504	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	18957414	MGI
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	22988117	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	22988117	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	21062744	MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA IDA: 通过直接分析推断	23040477	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	18467660	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18436640	MGI
enables lysine-acetylated histone binding	IDA IDA: 通过直接分析推断	23798425	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	17093407	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	18400104	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	20123909	MGI
enables transcription factor binding	IPI IPI: 通过物理相互作用推断	18957414	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of BMP signaling pathway	IDA IDA: 通过直接分析推断	16801560	MGI
involved in cell dedifferentiation	IDA IDA: 通过直接分析推断	23040477	MGI
acts upstream of or within embryo development	IMP IMP: 通过突变表型推断	12787504	MGI
involved in embryonic pattern specification	IEP IEP: 通过表达模式推断	15108323	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	17267691	MGI
involved in gonad development	IEP IEP: 通过表达模式推断	15108323	MGI
acts upstream of mesodermal cell fate commitment	IDA IDA: 通过直接分析推断	16801560	MGI
acts upstream of mesodermal cell fate commitment	IGI IGI: 通过遗传相互作用推断	16801560	MGI
acts upstream of or within mesodermal cell fate commitment	IGI IGI: 通过遗传相互作用推断	16801560	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: 通过直接分析推断	16801560	MGI
acts upstream of or within negative regulation of cell fate commitment	IDA IDA: 通过直接分析推断	16801560	MGI
acts upstream of or within negative regulation of cell fate commitment	IGI IGI: 通过遗传相互作用推断	16801560	MGI
acts upstream of or within negative regulation of stem cell differentiation	IDA IDA: 通过直接分析推断	17940068	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	16801560	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21385842	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18957414	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	20937355	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	16259959	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IDA IDA: 通过直接分析推断	16259959	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20937355	MGI
involved in regulation of stem cell division	IDA IDA: 通过直接分析推断	23040477	MGI
acts upstream of or within response to retinoic acid	IDA IDA: 通过直接分析推断	18400104	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: 通过直接分析推断	16801560	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	12787504	MGI
acts upstream of stem cell differentiation	IDA IDA: 通过直接分析推断	17940068	MGI
acts upstream of or within stem cell differentiation	IDA IDA: 通过直接分析推断	20123909	MGI
acts upstream of or within stem cell differentiation	IMP IMP: 通过突变表型推断	16894029	MGI
acts upstream of or within stem cell division	IDA IDA: 通过直接分析推断	12787505	MGI
involved in stem cell population maintenance	IEP IEP: 通过表达模式推断	15108323	MGI
acts upstream of or within stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	17938240	MGI
involved in stem cell population maintenance	IMP IMP: 通过突变表型推断	25825768	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in chromatin	IDA IDA: 通过直接分析推断	23798425	MGI
NOT located in condensed chromosome	IMP IMP: 通过突变表型推断	27723719	MGI
located in nucleoplasm	IDA IDA: 通过直接分析推断	21076177	MGI
is active in nucleus	IDA IDA: 通过直接分析推断	23798425	MGI
located in nucleus	IDA IDA: 通过直接分析推断	15582778	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

homeobox protein NANOG

ES cell-associated protein 4	early embryo specific expression NK family
early embryo specific expression NK-type homeobox protein	homeobox transcription factor Nanog

Nanog 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Nanog	Q80Z64	Pou5f1	Mus musculus	P20263	Anti Tag CoIP	17093407
种属内	Nanog	Q80Z64	Pou5f1	Mus musculus	P20263	Pull Down	17093407
种属内	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	TAP	17093407
种属内	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	Anti Bait CoIP	17093407
种属内	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	Pull Down	17093407
种属内	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Pull Down	17093407
种属内	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Anti Tag CoIP	23892456
种属内	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	TAP	17093407
种属内	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Anti Tag CoIP	17093407
种属内	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	Pull Down	17093407
种属内	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	Anti Tag CoIP	17093407
种属内	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	TAP	17093407
种属内	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Pull Down	17093407
种属内	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Anti Tag CoIP	17093407
种属内	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Anti Tag CoIP	23892456
种属内	Nanog	Q80Z64	Sox2	Mus musculus	P48432	Pull Down	23892456
种属内	Nanog	Q80Z64	Sox2	Mus musculus	P48432	Anti Tag CoIP	23892456
种属内	Nanog	Q80Z64	Pin1	Mus musculus	Q9QUR7	Anti Bait CoIP	20622153

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-17602	Amcasertib	Inhibitor	98.07%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12303	OAC1	Activator	99.56%	否
HY-18772	O4I2	Activator	99.30%	否
HY-119672	Oct4 inducer-1	Activator	98.27%	否
HY-RS09019	NANOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-119666	Rooperol	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Nanog	NCBI	NCBI:79923

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Nanog - Nanog homeobox Gene

关于 Nanog

功能概要

Nanog 基因产物(4)

Nanog 蛋白互作信息

直系同源

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Nanog - Nanog homeobox Gene

关于 Nanog

功能概要

Nanog 基因产物(4)

Nanog 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z