2. Gene
  3. Pin1 - peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Gene

Pin1 - peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: D9Bwg1161e; 0610025L01Rik

基因 ID: 23988 | 基因类型: protein coding

关于 Pin1

功能概要

Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein peptidyl-prolyl isomerization; and protein stabilization. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol and nucleus. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Apr 2022]

Pin1 基因产物(2)

mRNA Protein Name
NM_001364495.1 NP_001351424.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 2
NM_023371.4 NP_075860.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
22645310 MGI
enables cytoskeletal motor activity IMP
IMP: 通过突变表型推断
22645310 MGI
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
16554819 MGI
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
23362255 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17347650 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of amyloid-beta formation IMP
IMP: 通过突变表型推断
16554819 MGI
involved in neuron differentiation IMP
IMP: 通过突变表型推断
22645310 MGI
involved in protein peptidyl-prolyl isomerization IDA
IDA: 通过直接分析推断
16554819 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
11533658 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12810604 MGI
acts upstream of or within regulation of cytokinesis IMP
IMP: 通过突变表型推断
19638580 MGI
involved in regulation protein catabolic process at postsynapse EXP
EXP: 通过实验结果推断
28458925 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
28458925 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
28458925 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
28458925 MGI
involved in synapse organization IMP
IMP: 通过突变表型推断
22645310 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
22645310 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
28458925 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28458925 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
28458925 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
28458925 MGI
located in nucleus IDA
IDA: 通过直接分析推断
22645310 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PPIase Pin1

peptidyl-prolyl cis-trans isomerase Pin1

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

rotamase Pin1

Pin1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pin1 Q9QUR7 Tp53 Mus musculus P02340
Anti Bait CoIP
21741598
种属内
Pin1 Q9QUR7 Gphn Mus musculus Q8BUV3
Pull Down
17347650
种属内
Pin1 Q9QUR7 Gphn Mus musculus Q8BUV3
IF
17347650
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139361 Sulfopin Inhibitor 99.69% 否
HY-123847 KPT-6566 Inhibitor ≥98.0% 否
HY-128034 PPIase-Parvulin inhibitor Inhibitor 99.79% 否
HY-153675 BCPA Modulator 98.51% 否
HY-P4359 Suc-AEPF-AMC Inhibitor 98.67% 否
HY-128592 TAB29 Inhibitor / 否
HY-143903 ZL-Pin13 Inhibitor / 否
HY-170429 BJP-07-017-3 Inhibitor / 否
HY-137122 3-Pyridine toxoflavin Inhibitor / 否
HY-168036 PIN1 inhibitor 3 Inhibitor / 否
HY-168037 PROTAC PIN1 degrader-1 / 否
HY-143902 ZL-Pin01 Inhibitor / 否
HY-164895 PIN1 degrader-1 Degrader / 否
HY-12135 Poloxipan Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pin1 NCBI NCBI:5300
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