Trp53 - transformation related protein 53 Gene

中文名称：转化相关蛋白53

种属: Mus musculus

同用名: bbl; bfy; bhy; p44; p53; Tp53

关于 Trp53

功能概要

该基因编码肿瘤蛋白 p53，它响应不同的细胞应激以调节诱导细胞周期停滞、细胞凋亡、衰老、DNA 修复或代谢变化的靶基因。 p53 蛋白在正常细胞中以低水平表达，在各种转化细胞系中以高水平表达，据信它有助于转化和恶性肿瘤。 p53 是一种 DNA 结合蛋白，包含转录激活、DNA 结合和寡聚化结构域。它被假定与 p53 结合位点结合并激活抑制生长和/或侵袭的下游基因的表达，从而起到肿瘤抑制因子的作用。缺乏该基因的小鼠发育正常，但易患自发性肿瘤。迄今为止的证据表明，与人类基因的替代启动子相比，该基因包含一个启动子，并转录一些编码不同同种型的剪接变体，尽管尚未确定某些变体的生物学有效性或全长性质. [RefSeq 提供，2008 年 7 月]

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]