2. Gene
  3. Ccr5 - C-C motif chemokine receptor 5 Gene

Ccr5 - C-C motif chemokine receptor 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CC 基序趋化因子受体 5

种属: Rattus norvegicus

同用名: Ckr5; Cmkbr5

基因 ID: 117029 | 基因类型: protein coding

关于 Ccr5

Primary_assembly 8: 123,752,325-123,759,260 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 151 orthologues, 24 paralogues and is associated with 98 phenotypes. Biased expression in Spleen (RPKM 251.4), Thymus (RPKM 8.4) and 8 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶结合活性。参与多个过程，包括神经系统发育；细胞因子产生的正调节；和对细菌的反应。位于细胞表面和内体。用于研究老年痴呆症；瘟疫;和视觉性癫痫。多种疾病的生物标志物，包括动脉疾病（多种）；糖尿病（多发性）；晚期肾脏疾病;睾丸炎;和葡萄膜炎（多发）。该基因的人类直系同源物与多种疾病有关，包括川崎病；西尼罗热；自身免疫性疾病（多种）；铍中毒；和结节病（多发）。与人 CCR5（CC 基序趋化因子受体 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity. Involved in several processes, including nervous system development; positive regulation of cytokine production; and response to bacterium. Located in cell surface and endosome. Used to study Alzheimer's disease; plague; and visual epilepsy. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif Chemokine Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccr5 基因产物(1)

mRNA Protein Name
NM_053960.3 NP_446412.2 C-C chemokine receptor type 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14674010 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
14674010 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
23110133 RGD
involved in defense response to bacterium IEP
IEP: 通过表达模式推断
9670989 RGD
involved in fat cell differentiation IEP
IEP: 通过表达模式推断
17286602 RGD
involved in forebrain development IEP
IEP: 通过表达模式推断
16516309 RGD
involved in inflammatory response to antigenic stimulus IEP
IEP: 通过表达模式推断
14674010 RGD
involved in negative regulation of axon extension IMP
IMP: 通过突变表型推断
16537566 RGD
involved in negative regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
20940264 RGD
involved in positive regulation of cell killing IMP
IMP: 通过突变表型推断
20940264 RGD
involved in positive regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
16622027 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
23999490 RGD
involved in positive regulation of fever generation IMP
IMP: 通过突变表型推断
15066130 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19559698 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16790532 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
16790532 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
19034668 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
19559698 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16790532 RGD
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
20940264 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
16937495 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
19104678 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16320322 RGD
located in endosome IDA
IDA: 通过直接分析推断
12004163 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ccr5 蛋白结构

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (32 - 309)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (32 - 59)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (66 - 91)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (102 - 132)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (144 - 166)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (192 - 221)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (229 - 259)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (277 - 302)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 5

C-C CKR-5

CC-CKR-5

CCR-5

MIP-1 alpha receptor

chemokine (C-C motif) receptor 5

chemokine (C-C) receptor 5

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13004 Maraviroc Antagonist 99.88% 是
HY-117621 PF-04634817 Antagonist 98.87% 否
HY-117621A PF-04634817 succinate Antagonist 99.50% 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-14882 Cenicriviroc Antagonist 99.01% Phase 3
HY-14882A Cenicriviroc Mesylate Antagonist 99.04% Phase 3
HY-17377 Vicriviroc maleate Antagonist 99.91% Phase 3
HY-17450A Aplaviroc hydrochloride Antagonist 99.93% Phase 3
HY-17450 Aplaviroc Antagonist / Phase 3
HY-109593 BMS-813160 Antagonist 99.93% Phase 2
HY-P1034 DAPTA Inhibitor 99.85% Phase 2
HY-14230 INCB9471 Antagonist / Phase 2
HY-19974 TAK-220 Antagonist 99.95% Phase 1
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13406 TAK-779 Antagonist 99.73% 否
HY-101713 Ilacirnon Inhibitor 99.87% 否
HY-119101 AZD-5672 Antagonist 95.74% 否
HY-P4191 Met-RANTES (human) Antagonist / 否
HY-111069 Nifeviroc Inhibitor 98.17% 否
HY-152131 CCR5 antagonist 2 Antagonist / 否
HY-103406 PNU-177864 Inhibitor / 否
HY-162512 CB-0821 Inhibitor / 否
HY-111321 Fuscin Inhibitor / 否
HY-123902 Ophiobolin C Inhibitor / 否
HY-108432 BMS-741672 Antagonist / 否
HY-152132 CCR5 antagonist 3 Inhibitor / 否
HY-P4191A Met-RANTES (human) (acetate) Antagonist 99.62% 否
HY-100261 CCR5 antagonist 1 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr5 NCBI NCBI:1234
Mus musculus Ccr5 NCBI NCBI:12774
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