Ccr5 - chemokine (C-C motif) receptor 5 Gene

中文名称：趋化因子 (CC 基序) 受体 5

种属: Mus musculus

同用名: AM4-7; CD195; Cmkbr5

关于 Ccr5

功能概要

该基因编码的蛋白可启动 CC 趋化因子结合活性和 CC 趋化因子受体活性。参与巨噬细胞凋亡过程的负调控。在防御反应的上游或内部行动。位于质膜外侧。以多种结构表达，包括消化系统；脑;淋巴系统腺体；肝脏和胆道系统；和生殖系统。用于研究冠状病毒传染病。该基因的人类直系同源物与多种疾病有关，包括川崎病；西尼罗热；自身免疫性疾病（多种）；铍中毒；和结节病（多发）。与人 CCR5（CC 基序趋化因子受体 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif Chemokine Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]