2. Gene
  3. Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：BCL2 样 11 (细胞凋亡促进因子)

种属: Mus musculus

同用名: Bim; Bod; bcl2-L-11; 1500006F24Rik

基因 ID: 12125 | 基因类型: protein coding

关于 Bcl2l11

Chromosome 2: 127,967,958-128,004,467 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 84 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues.

功能概要

该基因编码的蛋白可启动动力蛋白复合物结合活动；微管结合活性；和蛋白激酶结合活性。参与对内质网应激的反应。作用于多个过程的上游或内部，包括动物器官发育；凋亡信号通路；和淋巴细胞稳态。位于线粒体中。是膜的外在成分。 Bcl-2 家族蛋白复合物的一部分。在大脑中表达；头发外根鞘；后肾;脾;和躯干未分段的间充质。与人类 BCL2L11 同源（BCL2 like 11）。 [由基因组资源联盟提供，2022 年 4 月]

Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 Family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 基因产物(10)

mRNA Protein Name
NM_001406060.1 NP_001392989.1 bcl-2-like protein 11 isoform 6
NM_009754.3 NP_033884.1 bcl-2-like protein 11 isoform 3
NM_001291016.1 NP_001277945.1 bcl-2-like protein 11 isoform 5
NM_001406061.1 NP_001392990.1 bcl-2-like protein 11 isoform 7
NM_207680.2 NP_997563.1 bcl-2-like protein 11 isoform 1
NM_207681.2 NP_997564.1 bcl-2-like protein 11 isoform 2
NM_001406059.1 NP_001392988.1 bcl-2-like protein 11 isoform 6
NM_001406057.1 NP_001392986.1 bcl-2-like protein 11 isoform 2
NM_001284410.3 NP_001271339.2 bcl-2-like protein 11 isoform 4
NM_001406058.1 NP_001392987.1 bcl-2-like protein 11 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
16832056 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14561217 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20371704 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within B cell homeostasis IMP
IMP: 通过突变表型推断
16055554 MGI
acts upstream of T cell apoptotic process IGI
IGI: 通过遗传相互作用推断
16832056 MGI
acts upstream of T cell apoptotic process IMP
IMP: 通过突变表型推断
16832056 MGI
acts upstream of or within T cell homeostasis IGI
IGI: 通过遗传相互作用推断
17591857 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
16270031 MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of cell cycle IMP
IMP: 通过突变表型推断
17705137 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: 通过突变表型推断
17276340 MGI
acts upstream of or within developmental pigmentation IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within ear development IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
15967824 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
16282979 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within leukocyte homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within leukocyte homeostasis IMP
IMP: 通过突变表型推断
15967824 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
16270031 MGI
acts upstream of or within lymphocyte homeostasis IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: 通过突变表型推断
11709185 MGI
acts upstream of or within male gonad development IGI
IGI: 通过遗传相互作用推断
16270031 MGI
acts upstream of or within mammary gland development IMP
IMP: 通过突变表型推断
17276340 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within positive regulation of T cell apoptotic process IGI
IGI: 通过遗传相互作用推断
16832056 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
16832056 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17276340 MGI
acts upstream of or within positive regulation of cell cycle IMP
IMP: 通过突变表型推断
17705137 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15967824 MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
16270031 MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within positive regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within regulation of developmental pigmentation IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within regulation of organ growth IMP
IMP: 通过突变表型推断
17276340 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
21159964 MGI
acts upstream of or within spermatogenesis IGI
IGI: 通过遗传相互作用推断
16270031 MGI
acts upstream of or within spleen development IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within symbiont-mediated activation of host apoptosis IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within thymocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within thymus development IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within tube formation IMP
IMP: 通过突变表型推断
17276340 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Bcl-2 family protein complex IMP
IMP: 通过突变表型推断
16645638 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15136728 MGI
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
15136728 MGI
located in membrane IDA
IDA: 通过直接分析推断
15136728 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
15136728 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bcl2l11 蛋白结构

Bim_N

Bim_N: pfam06773 (3 - 39)

Bclx_interact

Bclx_interact: pfam08945 (128 - 163)

  • 0
  • 100
  • 196 a.a.
蛋白主名 其他名称

bcl-2-like protein 11

Bcl2 interacting mediator of cell death

bcl2-interacting mediator of cell death

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153953 Bcl-2-IN-11 Inhibitor / 否
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / 否
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / 否
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcl2l11 NCBI NCBI:10018
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