Cxcr4 - chemokine (C-X-C motif) receptor 4 Gene

中文名称：趋化因子 (CXC 基序) 受体 4

种属: Mus musculus

同用名: CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1

关于 Cxcr4

功能概要

预计该基因编码的蛋白具有多种功能，包括趋化因子受体活性；细胞骨架蛋白结合活性；和泛素蛋白连接酶结合活性。参与髓鞘维护；冷诱导产热的正调节；和少突胶质细胞分化的正调节。作用于多个过程的上游或内部，包括循环系统发育；配子世代；和神经系统发育。位于细胞间连接处；质膜的外侧；和生长锥。以多种结构表达，包括消化系统；心血管系统;胚胎间充质；胚外成分；和神经系统。用于研究 WHIM 综合症。该基因的人类直系同源物与 WHIM 综合征有关；血液系统癌症（多发性）；白细胞减少症;骨质疏松症；和胰腺癌。与人 CXCR4（CXC 基序趋化因子受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including Chemokine Receptor activity; cytoskeletal protein binding activity; and ubiquitin protein Ligase binding activity. Involved in myelin maintenance; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including circulatory system development; gamete generation; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic Cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]