2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. Mavorixafor hydrochloride

Mavorixafor hydrochloride  (Synonyms: AMD-070 hydrochloride; AMD-11070 hydrochloride)

目录号: HY-50101C
产品使用指南

摩尔计算器

Mavorixafor (AMD-070) hydrochloride 是一种有效的，选择性的，具有口服活性的 CXCR4 拮抗剂，能够拮抗 125I-SDF 与 CXCR4 结合，IC50 值为 13 nM。Mavorixafor hydrochloride 能够抑制 HIV-1 (NL4.3 strain) 的复制，在 MT-4 和 PBMCs 细胞中，IC50 值分别为 1 nM 和 9 nM。Mavorixafor hydrochloride 可用于研究 WHIM 综合征。

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Mavorixafor hydrochloride Chemical Structure

Mavorixafor hydrochloride Chemical Structure

CAS No. : 880549-30-4

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Mavorixafor hydrochloride 的其他形式现货产品:

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Other Forms of Mavorixafor hydrochloride:

Mavorixafor hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome[1].

IC50 & Target[1]

125I-CXCL12-CXCR4

13 nM (IC50)

HIV-1 (NL4.3 strain)

1 nM (IC50, In MT-4 cells)

HIV-1 (NL4.3 strain)

9 nM (IC50, In PBMCs)

HIV-1 (NL4.3 strain)

3 nM (IC90, In MT-4 cells)

HIV-1 (NL4.3 strain)

26 nM (IC90, In PBMCs)

体外研究
(In Vitro)

Mavorixafor (AMD-070) hydrochloride 对其他趋化因子受体（CCR1、CCR2b、CCR4、CCR5、CXCR1 和 CXCR2）没有影响[1]。
Mavorixafor（6.6 μM；14-21 天）hydrochloride 显着抑制 B88-SDF-1 细胞的贴壁依赖性生长。Mavorixafor hydrochloride 显着损害 B88-SDF-1 细胞增强的运动性。Mavorixafor hydrochloride 还显着抑制 B88-SDF-1 细胞的迁移和 Matrigel 侵袭[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mavorixafor hydrochloride 相关抗体:

Cell Invasion Assay[2]

Cell Line: B88-SDF-1 cells
Concentration: 6.6 µM
Incubation Time: 48 h
Result: Significantly inhibited the migration and Matrigel invasion of B88-SDF-1 cells.
体内研究
(In Vivo)

Mavorixafor (AMD-070) hydrochloride 对其他趋化因子受体（CCR1、CCR2b、CCR4、CCR5、CXCR1 和 CXCR2）没有影响[1]。
Mavorixafor（6.6 μM；14-21 天）hydrochloride 显着抑制 B88-SDF-1 细胞的贴壁依赖性生长。Mavorixafor hydrochloride 显着损害 B88-SDF-1 细胞增强的运动性。Mavorixafor hydrochloride 还显着抑制 B88-SDF-1 细胞的迁移和 Matrigel 侵袭[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells[2]
Dosage: 2 mg/kg
Administration: Oral administration; once a day; for 49 days
Result: A significant reduction in the number of metastatic lung nodules was observed in the mice.
分子量

385.93

Formula

C21H28ClN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mavorixafor hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mavorixafor880549-30-4AMD-070AMD-11070AMD070AMD 070AMD11070AMD 11070CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusCXCR4HIV-1Inhibitorinhibitorinhibit

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目录号：
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