Drd1 - dopamine receptor D1 Gene

中文名称：多巴胺受体 D1

种属: Mus musculus

同用名: Drd-1; Drd1a; Gpcr15; C030036C15Rik

关于 Drd1

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性和多巴胺神经递质受体活性，通过 Gs 偶联。参与突触后结构的修饰和突触小泡胞吐的调节。作用于多个过程的上游或内部，包括中枢神经系统发育；学习或记忆；和化学突触传递的调节。位于多个细胞成分中，包括 GABA 能突触；树突棘;和谷氨酸能突触。是突触前膜的组成部分。是突触后膜的组成部分。以多种结构表达，包括消化系统；脑;泌尿生殖系统；外皮系统；和感觉器官。用于研究亨廷顿舞蹈病。该基因的人类直系同源物与高血压和肾衰竭有关。与人类 DRD1（多巴胺受体 D1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in modification of postsynaptic structure and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and glutamatergic synapse. Is integral component of presynaptic membrane. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (Dopamine Receptor D1). [provided by Alliance of Genome Resources, Apr 2022]