2. Gene
  3. DOCK11 - dedicator of cytokinesis 11 Gene

DOCK11 - dedicator of cytokinesis 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胞质分裂因子 11

种属: Homo sapiens

同用名: ACG; ZIZ2; bB128O4.1

基因 ID: 139818 | 基因类型: protein coding

关于 DOCK11

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,495,815-118,686,147 (from NCBI)

This gene has 4 transcripts (splice variants), 226 orthologues and 10 paralogues. Broad expression in fat (RPKM 20.0), lymph node (RPKM 11.7) and 19 other tissues.

功能概要

预测可启用胍基核苷酸交换因子活性。预计参与多个过程，包括边缘区 B 细胞分化； GTP 酶活性的正调节；和 filopodium 组件的正向调节。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DOCK11 基因产物(1)

mRNA Protein Name
NM_144658.4 NP_653259.3 dedicator of cytokinesis protein 11
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25074804 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
37342957 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOCK11 蛋白结构

DUF3398

DUF3398: Domain of unknown function (DUF3398) (51 - 145)

PH

PH: PH domain (166 - 271)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (635 - 827)

DHR-2

DHR-2: Dock homology region 2 (1852 - 2028)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2073 a.a.
蛋白主名 其他名称

dedicator of cytokinesis protein 11

Activated Cdc42-associated guanine nucleotide exchange factor, ACG

关联疾病

疾病名称 别名
Viral Laryngitis
Brachydactyly, Type C

Brachydactyly Type C

BDC

Brachydactyly Haws Type

Brachydactyly, Haws Type

Brachydactyly C
Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03923 DOCK11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DOCK11 VGNC VGNC:40045
Felis catus DOCK11 VGNC VGNC:97404
Mus musculus DOCK11 MGD MGI:1923224
Bos taurus DOCK11 VGNC VGNC:28156
Rattus norvegicus DOCK11 RGD RGD:1564707
Macaca mulatta DOCK11 VGNC VGNC:71890
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z