1. Gene
  2. Gli1 - GLI family zinc finger 1 Gene

Gli1 - GLI family zinc finger 1 Gene

中文名称:GL I 家族锌指 1

种属: Rattus norvegicus

同用名: Gli

基因 ID: 140589 | 基因类型: protein coding

关于 Gli1

Primary_assembly 7: 63,156,926-63,169,251 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 201 orthologues, 14 paralogues and is associated with 27 phenotypes. Biased expression in Uterus (RPKM 36.2), Lung (RPKM 17.8) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能,包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性; RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性;和微管结合活性。参与肝再生和前列腺发育。预测位于轴丝;胞质溶胶;和核质。预计在细胞质和细胞核中有活性。高眼压症和恶变前肿瘤的生物标志物。与人类 GLI1(GLI 家族锌指 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in liver regeneration and prostate gland development. Predicted to be located in axoneme; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Biomarker of ocular hypertension and pre-malignant neoplasm. Orthologous to human GLI1 (Gli family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Gli1 基因产物(1)

mRNA Protein Name
NM_001191910.1 NP_001178839.1 zinc finger protein GLI1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in liver regeneration IEP
IEP: 通过表达模式推断
22024090 RGD
involved in prostate gland development IEP
IEP: 通过表达模式推断
15328011 RGD
involved in spermatid development IEP
IEP: 通过表达模式推断
21893610 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Gli1 蛋白结构

COG5236

COG5236: cl28715 (195 - 432)

FOXP-CC

FOXP-CC: cl24666 (236 - 264)

ZF_C2H2

ZF_C2H2: sd00017 (302 - 324)

ZF_C2H2

ZF_C2H2: sd00017 (332 - 355)

ZF_C2H2

ZF_C2H2: sd00017 (363 - 384)

PHA03247

PHA03247: cl33720 (560 - 866)

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  • 1109 a.a.
蛋白主名 其他名称

zinc finger protein GLI1

GLI-Kruppel family member GLI1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gli1 NCBI NCBI:2735