2. PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway TGF-beta/Smad
  3. Akt Gli JNK PKA
  4. Adropin (34-76) (human, mouse, rat)

Adropin (34-76) (human, mouse, rat) 

目录号: HY-P4860 纯度: 99.87%
COA 产品使用指南

摩尔计算器

Adropin (34-76) 是 Adropin 的分泌结构域。Adropin (34-76) 在肝细胞中可抑制 cAMP 水平和葡萄糖生成，具有降血糖的作用。Adropin (34-76) 通过抑制 GLI1 信号通路发挥抗纤维化的作用。

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Custom Peptide Synthesis

Adropin (34-76) (human, mouse, rat) Chemical Structure

Adropin (34-76) (human, mouse, rat) Chemical Structure

CAS No. : 1802086-30-1

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5 mg ￥4800
In-stock
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25 mg 现货 询价
50 mg 现货 询价
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Customer Review

Adropin (34-76) (human, mouse, rat) 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

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JNK1 JNK2 JNK3 JNK

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PKA PKAR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway[1][2].

体外研究
(In Vitro)

Adropin (34-76) (100 nM；3 小时) 在原代培养的小鼠肝细胞中抑制葡萄糖生成[1]。
Adropin (34-76) (100 nM；3 小时) 在 HepG2 肝细胞中降低 cAMP 水平[1]。
Adropin (34-76) (0-100 ng/mL；48 小时) 在成纤维细胞中抑制 TGF-β 诱导的细胞活化、胶原蛋白的产生和纤维化重塑[2]。
Adropin (34-76) (100 ng/mL；48 小时) 在成纤维细胞中通过抑制 GLI1 信号通路发挥抗纤维化的作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adropin (34-76) (human, mouse, rat) 相关抗体:

Western Blot Analysis [2]

Cell Line: TGF-β treated fibroblasts
Concentration: 0, 10, 50 and 100 ng/mL
Incubation Time: 48 h
Result: Reduced the levels of α-smooth muscle actin and type І collagen in a dose-dependent manner.

Immunofluorescence [2]

Cell Line: TGF-β treated fibroblasts
Concentration: 100 ng/mL
Incubation Time: 48 h
Result: Reduced GLI1 and GLI2 staining intensity but did not interfere with the nuclear translocation of GLI1 or GLI2.
体内研究
(In Vivo)

Adropin (34-76) (450 nmol/kg ≈ 2 mg/kg；腹腔注射；48 小时内注射 5 次) 在小鼠饮食诱导肥胖模型中具有降血糖的作用[1]。
Adropin (34-76) (10 μg/kg/h；皮下渗透泵；25 天) 在小鼠纤维化模型中具有改善作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DIO B6 mice[1]
Dosage: 450 nmol/kg ≈ 2 mg/kg
Administration: Five intraperitoneal injections over a 48-h period
Result: Enhanced intracellular signaling actions underlying insulin’s effect on hepatic glucose metabolism.
Alleviated hepatic ER stress responses.
Diminished JNK and PKA signaling in the liver.
Down-regulates hepatic lipogenic genes.
Altered the phosphorylation levels of IP3R in the liver.
Animal Model: Mouse with fibrosis model[2]
Dosage: 10 μg/kg/h
Administration: Subcutaneous osmotic pump; 25 days
Result: Ameliorated allogeneic bone marrow transplantation (alloBMT)-induced skin fibrosis, with reduced dermal thickness, lower myofibroblast counts, and decreased hydroxyproline content.
Ameliorated alloBMT-induced pulmonary fibrosis, with reduced Ashcroft scores and hydroxyproline content.
分子量

4499.82

Formula

C190H293N55O68S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Cys-His-Ser-Arg-Ser-Ala-Asp-Val-Asp-Ser-Leu-Ser-Glu-Ser-Ser-Pro-Asn-Ser-Ser-Pro-Gly-Pro-Cys-Pro-Glu-Lys-Ala-Pro-Pro-Pro-Gln-Lys-Pro-Ser-His-Glu-Gly-Ser-Tyr-Leu-Leu-Gln-Pro (Disulfide bridge: Cys1-Cys23)
Sequence Shortening

CHSRSADVDSLSESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP (Disulfide bridge: Cys1-Cys23)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (11.11 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2222 mL 1.1112 mL 2.2223 mL
5 mM 0.0444 mL 0.2222 mL 0.4445 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Adropin (34-76) (human, mouse, rat) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2222 mL 1.1112 mL 2.2223 mL 5.5558 mL
5 mM 0.0444 mL 0.2222 mL 0.4445 mL 1.1112 mL
10 mM 0.0222 mL 0.1111 mL 0.2222 mL 0.5556 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adropin (34-76) (human, mouse, rat)1802086-30-1AktGliJNKPKAPKBProtein kinase Bc-Jun N-terminal kinaseProtein kinase AHepG2 cellsHepatocytesFibrosis modelDIO modelFibroblastsInhibitorinhibitorinhibit

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