2. Gene
  3. Fap - fibroblast activation protein Gene

Fap - fibroblast activation protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: SIMP

基因 ID: 14089 | 基因类型: protein coding

关于 Fap

功能概要

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]

Fap 基因产物(1)

mRNA Protein Name
NM_007986.3 NP_032012.1 prolyl endopeptidase FAP
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
9688278 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in melanocyte apoptotic process IDA
IDA: 通过直接分析推断
15133496 MGI
involved in melanocyte proliferation IDA
IDA: 通过直接分析推断
15133496 MGI
involved in negative regulation of cell proliferation involved in contact inhibition IDA
IDA: 通过直接分析推断
15133496 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
15133496 MGI
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
15133496 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
24038871 MGI
located in basal part of cell IDA
IDA: 通过直接分析推断
24038871 MGI
located in cell surface IDA
IDA: 通过直接分析推断
15133496 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prolyl endopeptidase FAP

FAPalpha

dipeptidyl peptidase FAP

fibroblast activation protein alpha

gelatine degradation protease FAP

integral membrane serine protease

post-proline cleaving enzyme

seprase

serine integral membrane protease

surface-expressed protease

重组 Fap 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77934 FAP Protein, Mouse (HEK293, His) P97321-1 (L26-D761) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P3392 Zilganersen / Phase 3
HY-137331 FAPI-46 98.57% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99269 Sibrotuzumab ≥95.0% Phase 2
Pre-clinical Phase
生物活性分子 (43)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101801 Ac-Gly-BoroPro ≥98.0% 否
HY-147057 Rofapitide tetraxetan 99.54% 否
HY-128643 FAPI-4 98.42% 否
HY-145983 Suc-Gly-Pro-AMC 99.16% 否
HY-153552A NH2-UAMC1110 TFA Inhibitor 99.89% 否
HY-100684 UAMC-1110 Inhibitor 99.58% 否
HY-147173 FAPI-74 99.84% 否
HY-145938 OncoFAP 99.77% 否
HY-P10131 3BP-3940 99.96% 否
HY-47979A FAP-IN-2 TFA Inhibitor 99.92% 否
HY-47979 FAP-IN-2 Inhibitor 99.82% 否
HY-136641 NOTA-FAPI Inhibitor 99.26% 否
HY-164725 FAPI-mFS Inhibitor 99.78% 否
HY-164316 FT-FAPI-12_9 99.07% 否
HY-164364A DOTAGA.(SA.FAPi)2 TFA Inhibitor 96.81% 否
HY-139401 FAPI-34 99.67% 否
HY-P3441A 3BP-4089 TFA 99.64% 否
HY-128642 FAPI-2 98.94% 否
HY-125366 ARI-3099 / 否
HY-D2363 DOTA.SA.FAPi TFA Inhibitor 99.26% 否
HY-161074 PNT6555 96.55% 否
HY-147057A Rofapitide tetraxetan acetate / 否
HY-P3392A Zilganersen sodium Inhibitor 91.43% 否
HY-164316A FT-FAPI-12_9 TFA 99.48% 否
HY-172317 AZD2389 Inhibitor / 否
HY-172137 FAPI-FUSCC-07 Ligand / 否
HY-146181 FSDD1I / 否
HY-161262 SB03178 Inhibitor / 否
HY-149860 FAP-IN-1 Inhibitor / 否
HY-148361 Fluorogen binding modulator-1 / 否
HY-153552 NH2-UAMC1110 Inhibitor / 否
HY-158326 FAP-IN-4 Inhibitor / 否
HY-128642A FAPI-2 TFA 98.05% 否
HY-146182 FSDD3I / 否
HY-103323 Fas C-Terminal Tripeptide Inhibitor / 否
HY-P3441 3BP-4089 / 否
HY-170779 DOTA-NI-FAPI-04 Inhibitor / 否
HY-146180 FSDD0I / 否
HY-D2281 FAP Ligand 2 / 否
HY-164364B DOTAGA.(SA.FAPi)2 analogue TFA Inhibitor / 否
HY-W668749 3BP-3580 Inhibitor / 否
HY-168278 Ga-CY03 Inhibitor / 否
HY-163079 AlF-PD-FAPI / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fap NCBI NCBI:2191
Macaca fascicularis Fap NCBI NCBI:102134935
Rattus norvegicus Fap NCBI NCBI:192203
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