FRMPD2 - FERM and PDZ domain containing 2 Gene

中文名称：含 FERM 和 PDZ 结构域 2

种属: Homo sapiens

同用名: PDZK4; PDZD5C; PDZK5C

关于 FRMPD2

功能概要

该基因编码一种外周膜蛋白，位于染色体 10q 的一个区域，该区域包含一个片段重复。这个基因拷贝是全长的，位于端粒复制区。该基因的另外两个更接近着丝粒的拷贝是部分的，可能代表假基因。这个全长基因似乎在细胞极化的建立和维持中起作用。该蛋白以 E-钙粘蛋白依赖性方式募集到细胞-细胞连接处，并选择性地定位于极化上皮细胞的基底外侧膜。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 12 月]

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two Other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]