1. Gene
  2. Fzd8 - frizzled class receptor 8 Gene

Fzd8 - frizzled class receptor 8 Gene

种属: Mus musculus

同用名: Fz8

基因 ID: 14370 | 基因类型: protein coding

关于 Fzd8

功能概要

Enables several functions, including PDZ domain binding activity; Wnt-activated receptor activity; and Wnt-protein binding activity. Involved in Wnt signaling pathway. Acts upstream of or within several processes, including T cell differentiation in thymus; angiogenesis; and positive regulation of JUN kinase activity. Located in plasma membrane. Part of Wnt-Frizzled-LRP5/6 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FZD8 (Frizzled class receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Fzd8 基因产物(1)

mRNA Protein Name
NM_008058.2 NP_032084.2 frizzled-8 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
11520064 MGI
enables Wnt receptor activity IPI
IPI: 通过物理相互作用推断
15454084 MGI
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
11357136 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11029007 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
11029007 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell differentiation in thymus IMP
IMP: 通过突变表型推断
11265645 MGI
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
19129494 MGI
involved in Wnt signaling pathway IDA
IDA: 通过直接分析推断
11357136 MGI
acts upstream of or within angiogenesis IDA
IDA: 通过直接分析推断
19129494 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
16543246 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
16115200 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
11265645 MGI
acts upstream of or within positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
15195140 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
15143170 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Wnt-Frizzled-LRP5/6 complex IDA
IDA: 通过直接分析推断
20093360 MGI
part of Wnt-Frizzled-LRP5/6 complex IPI
IPI: 通过物理相互作用推断
11029007 MGI
is active in neuronal dense core vesicle EXP
EXP: 通过实验结果推断
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
21321602 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15035989 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

frizzled-8

frizzled homolog 8

fz-8

Fzd8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Fzd8 Q61091 Igfbp4 Mus musculus P47879
Anti Tag CoIP
18528331
种属内
Fzd8 Q61091 Wnt3a Mus musculus P27467
Pull Down
31036956
种属内
Fzd8 Q61091 Wnt3a Mus musculus P27467
BLI
23791946
种属内
Fzd8 Q61091 Wnt3a Mus musculus P27467
Pull Down
22575959
种属内
Fzd8 Q61091 Wnt3a Mus musculus P27467
Anti Tag CoIP
18528331
种属内
Fzd8 Q61091 Gopc Mus musculus Q8BH60
Anti Tag CoIP
11520064
种属内
Fzd8 Q61091 Gopc Mus musculus Q8BH60
Pull Down
11520064
种属间
Fzd8 Q61091 WNT3 Homo sapiens P56703
X-Ray Diffraction
31036956
种属间
Fzd8 Q61091 WNT3 Homo sapiens P56703
GMS
31036956
种属间
Fzd8 Q61091 LRP6 Homo sapiens O75581
Pull Down
11029007
种属间
Fzd8 Q61091 wnt8 Crosspus laevis P28026
X-Ray Diffraction
22653731
种属间
Fzd8 Q61091 wnt8 Crosspus laevis P28026
Chromatography
22653731
种属间
Fzd8 Q61091 wnt8 Crosspus laevis P28026
SPR
22653731
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fzd8 NCBI NCBI:8325