1. Gene
  2. ADRA1D - adrenoceptor alpha 1D Gene

ADRA1D - adrenoceptor alpha 1D Gene

中文名称:肾上腺素能受体 alpha 1D

种属: Homo sapiens

同用名: DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2

基因 ID: 146 | 基因类型: protein coding

关于 ADRA1D

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,220,630-4,249,287 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues.

功能概要

α-1-肾上腺素能受体 (alpha-1-ARs) 是 G 蛋白偶联受体超家族的成员。它们激活有丝分裂反应并调节许多细胞的生长和增殖。有 3 种 alpha-1-AR 亚型:alpha-1A、-1B 和 -1D,所有这些都通过 G 蛋白的 Gq/11 家族发出信号,不同的亚型显示不同的激活模式。该基因编码 alpha-1D-肾上腺素能受体。类似于 alpha-1B-肾上腺素能受体基因,该基因包含 2 个外显子和一个中断编码区的内含子。[RefSeq 提供,2008 年 7 月]

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

ADRA1D 基因产物(1)

mRNA Protein Name
NM_000678.4 NP_000669.1 alpha-1D adrenergic receptor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
14645668 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16533813 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADRA1D 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (113 - 402)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
蛋白主名 其他名称

alpha-1D adrenergic receptor

adrenergic, alpha -1D-, receptor

ADRA1D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
ADRA1D P25100 Snta1 Mus musculus Q61234 16533813
种属内
ADRA1D P25100 SCRIB Homo sapiens Q14160
TAP
26617989
种属内
ADRA1D P25100 SCRIB Homo sapiens Q14160 26617989
种属内
ADRA1D P25100 SCRIB Homo sapiens Q14160 26617989
种属内
ADRA1D P25100 SCRIB Homo sapiens Q14160 27382054
种属内
ADRA1D P25100 SNTB2 Homo sapiens Q13425
TAP
26617989
种属内
ADRA1D P25100 SNTB2 Homo sapiens Q13425
TAP
18468998
种属内
ADRA1D P25100 SNTA1 Homo sapiens Q13424 26617989
种属内
ADRA1D P25100 SNTB2 Homo sapiens Q13425 27382054
种属内
ADRA1D P25100 SNTB2 Homo sapiens Q13425
TAP
21115837
种属内
ADRA1D P25100 SNTA1 Homo sapiens Q13424 26617989
种属内
ADRA1D P25100 SNTA1 Homo sapiens Q13424
TAP
26617989
种属内
ADRA1D P25100 SNTB2 Homo sapiens Q13425 18468998
种属内
ADRA1D P25100 SNTA1 Homo sapiens Q13424 18468998
种属内
ADRA1D P25100 SNTA1 Homo sapiens Q13424 27382054
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ureterolithiasis

Calculus Of Ureter

Ureteric Stone

Ureteral Calculi

Ureteric Calculus

Stone In The Ureter

Ureter Calculi

Ureteral Calculus Or Stone

Ureterolith

Ureterolithiasis Nos

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Gastroparesis

Gastroparesis Syndrome

Delayed Gastric Emptying

Gastric Atonia

Gastroparalysis

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Urethral Stricture

Ankylurethria

Urethral Stenosis

Urethral Contracture

Urethral Obstruction

Meatal Stenosis Nos

Constriction Of Urethra

Contraction Of Urethra

Stricture Of Urinary Meatus

Urethral Obliteration

Urethral Narrowing

Pinpoint Meatus

Pinhole Meatus Nos

Urethral Occlusion

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADRA1D RGD RGD:62064
Felis catus ADRA1D VGNC VGNC:59655
Canis familiaris ADRA1D VGNC VGNC:37674
Bos taurus ADRA1D VGNC VGNC:25695
Mus musculus ADRA1D MGD MGI:106673
Macaca mulatta ADRA1D VGNC VGNC:107732