2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. ADRA1D receptor antagonist 1 free base

ADRA1D receptor antagonist 1 free base 

目录号: HY-148252
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ADRA1D receptor antagonist 1 (free base) (化合物 (R)-9s) 是一种口服有效的、强效的和选择性的人类 α1D 肾上腺素受体 (α1D-AR) 拮抗剂 (Ki=1.6 nM)。ADRA1D receptor antagonist 1 (free base) 能剂量依赖性地抑制膀胱收缩，其 IC30 值为 15 nM。ADRA1D receptor antagonist 1 (free base) 可用于膀胱过度活动症 (如尿急、尿频和尿失禁) 的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 ADRA1D receptor antagonist 1 通常具有更好的水溶性和稳定性。

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ADRA1D receptor antagonist 1 free base Chemical Structure

ADRA1D receptor antagonist 1 free base Chemical Structure

CAS No. : 1191908-24-3

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ADRA1D receptor antagonist 1 free base 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADRA1D receptor antagonist 1 (free base) (compound (R)-9s) is an orally active, potent and selective human α1D-adrenoceptor (α1D-AR) antagonist (Ki=1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC30 value of 15 nM. ADRA1D receptor antagonist 1 (free base) can be used in studies of overactive bladder disorders such as urinary urgency, frequency and incontinence.

体内研究
(In Vivo)

ADRA1D receptor antagonist 1 (free base) (10 µg/kg; p.o.; single) inhibits cyclophosphamide-induced urinary frequency in rats[1].
ADRA1D receptor antagonist 1 (free base) (4.4 µg/kg; i.v.; single) inhibits bladder contraction with an IC 30 value of 15 nM in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats with cyclophosphamide-induced cystitis[1].
Dosage: 10 µg/kg
Administration: Oral administration; single
Result: Increased voiding intervals.
Animal Model: Rats with BOO (bladder outlet obstruction)[1].
Dosage: 4.4 µg/kg
Administration: Intravenous injection; single
Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase.
分子量

300.74

Formula

C15H13ClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADRA1D receptor antagonist 1 free base 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADRA1D receptor antagonist 11191908-24-3Adrenergic ReceptorBeta ReceptorOABoveractive bladderurinary urgencyfrequencyincontinenceInhibitorinhibitorinhibit

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