1. Gene
  2. CD300LF - CD300 molecule like family member f Gene

CD300LF - CD300 molecule like family member f Gene

中文名称:CD300 分子样家族成员 f

种属: Homo sapiens

同用名: CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13

基因 ID: 146722 | 基因类型: protein coding

关于 CD300LF

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,694,317-74,712,923 (from NCBI)

This gene has 10 transcripts (splice variants), 288 orthologues and 13 paralogues. Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues.

功能概要

该基因编码 CD300 蛋白家族的一个成员。该家族的成员是具有单个 IgV 样细胞外结构域的细胞表面糖蛋白,参与免疫反应的调节。编码的蛋白质是一种抑制性受体。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 1 月]

This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

CD300LF 基因产物(7)

mRNA Protein Name
NM_001289082.2 NP_001276011.1 CMRF35-like molecule 1 isoform 2
NM_001289083.2 NP_001276012.1 CMRF35-like molecule 1 isoform 3 precursor
NM_001289084.2 NP_001276013.1 CMRF35-like molecule 1 isoform 4
NM_001289085.2 NP_001276014.1 CMRF35-like molecule 1 isoform 5
NM_001289086.2 NP_001276015.1 CMRF35-like molecule 1 isoform 6
NM_001289087.2 NP_001276016.1 CMRF35-like molecule 1 isoform 7 precursor
NM_139018.5 NP_620587.2 CMRF35-like molecule 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide binding IDA
IDA: 通过直接分析推断
24035150 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20959446 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20959446 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in TRIF-dependent toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
22043923 GOA
involved in negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
22043923 GOA
involved in negative regulation of mast cell activation IDA
IDA: 通过直接分析推断
24035150 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD300LF 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (21 - 116)

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (157 - 260)

  • 0
  • 100
  • 200
  • 290 a.a.
蛋白主名 其他名称

CMRF35-like molecule 1

CD300 antigen-like family member F

重组 CD300LF 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71595 CD300LF Protein, Human (His) Q8TDQ1-1 (T20-S156) ≥95%

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CD300LF VGNC VGNC:70910
Mus musculus CD300LF MGD MGI:2442359
Rattus norvegicus CD300LF RGD RGD:1309733
Felis catus CD300LF VGNC VGNC:60611
Others CD300LF NCBI