2. Gene
  3. Grin2a - glutamate receptor, ionotropic, NMDA2A (epsilon 1) Gene

Grin2a - glutamate receptor, ionotropic, NMDA2A (epsilon 1) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NR2A; GluN2A; NMDAR2A; GluRepsilon1

基因 ID: 14811 | 基因类型: protein coding

关于 Grin2a

功能概要

Enables NMDA glutamate receptor activity and Calcium Channel activity. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including glutamatergic synapse; synaptic membrane; and synaptic vesicle. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

Grin2a 基因产物(1)

mRNA Protein Name
NM_008170.4 NP_032196.2 glutamate receptor ionotropic, NMDA 2A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to NMDA glutamate receptor activity IGI
IGI: 通过遗传相互作用推断
1374164 MGI
enables NMDA glutamate receptor activity IGI
IGI: 通过遗传相互作用推断
1377365 MGI
enables NMDA glutamate receptor activity IMP
IMP: 通过突变表型推断
7816096 MGI
contributes to calcium channel activity IGI
IGI: 通过遗传相互作用推断
1374164 MGI
enables calcium channel activity IMP
IMP: 通过突变表型推断
11160454 MGI
enables monoatomic cation channel activity IMP
IMP: 通过突变表型推断
8699248 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9003035 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion transport IGI
IGI: 通过遗传相互作用推断
1374164 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
11160454 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: 通过突变表型推断
9147327 MGI
NOT acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
16190898 MGI
acts upstream of or within directional locomotion IGI
IGI: 通过遗传相互作用推断
8987814 MGI
acts upstream of or within dopamine metabolic process IMP
IMP: 通过突变表型推断
11160454 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
8987814 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
8699248 MGI
involved in glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
25645137 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
9427357 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
9712642 MGI
acts upstream of or within locomotion IMP
IMP: 通过突变表型推断
11160454 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
20661302 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: 通过突变表型推断
16901514 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
9458051 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
12427824 MGI
acts upstream of or within negative regulation of protein catabolic process IGI
IGI: 通过遗传相互作用推断
15317856 MGI
acts upstream of or within neurogenesis IMP
IMP: 通过突变表型推断
12941447 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
17803966 MGI
acts upstream of protein catabolic process IGI
IGI: 通过遗传相互作用推断
15317856 MGI
acts upstream of or within protein localization to postsynaptic membrane IGI
IGI: 通过遗传相互作用推断
15317856 MGI
acts upstream of or within protein localization to postsynaptic membrane IMP
IMP: 通过突变表型推断
15317856 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
7816096 MGI
acts upstream of or within regulation of postsynaptic membrane potential IMP
IMP: 通过突变表型推断
16157280 MGI
involved in regulation of synaptic plasticity IDA
IDA: 通过直接分析推断
25645137 MGI
involved in regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
12427824 MGI
acts upstream of or within response to amphetamine IMP
IMP: 通过突变表型推断
15731593 MGI
acts upstream of or within response to ethanol IMP
IMP: 通过突变表型推断
11530236 MGI
acts upstream of or within response to wounding IGI
IGI: 通过遗传相互作用推断
9512392 MGI
acts upstream of or within response to wounding IMP
IMP: 通过突变表型推断
9822733 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
14750973 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
10694228 MGI
acts upstream of or within serotonin metabolic process IMP
IMP: 通过突变表型推断
11160454 MGI
acts upstream of or within sleep IMP
IMP: 通过突变表型推断
12754515 MGI
acts upstream of or within startle response IGI
IGI: 通过遗传相互作用推断
14985927 MGI
NOT acts upstream of or within startle response IMP
IMP: 通过突变表型推断
9718984 MGI
acts upstream of or within startle response IMP
IMP: 通过突变表型推断
11488959 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
7816096 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NMDA selective glutamate receptor complex IPI
IPI: 通过物理相互作用推断
7929101 MGI
located in cell surface IDA
IDA: 通过直接分析推断
17229826 MGI
located in cell surface IMP
IMP: 通过突变表型推断
17229826 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16814779 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19726645 MGI
located in membrane IDA
IDA: 通过直接分析推断
8840015 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
21558424 MGI
located in neuron projection IMP
IMP: 通过突变表型推断
21558424 MGI
located in postsynapse IDA
IDA: 通过直接分析推断
33158444 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
21664258 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
19726645 MGI
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
12103442 MGI
located in presynaptic membrane IDA
IDA: 通过直接分析推断
16157280 MGI
located in synapse IDA
IDA: 通过直接分析推断
14622577 MGI
located in synaptic membrane IDA
IDA: 通过直接分析推断
26609151 MGI
located in synaptic vesicle IDA
IDA: 通过直接分析推断
20418887 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate receptor ionotropic, NMDA 2A

N-methyl D-aspartate receptor subtype 2A

glutamate [NMDA] receptor subunit epsilon-1

Grin2a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Tag CoIP
16332682
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
31746486
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Y2H
9647694
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Crosslink
28713243
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
19240213
Intra Grin2a P35436 Dlg4 Mus musculus Q62108
Anti Bait CoIP
19243221
Intra Grin2a P35436 Patj Mus musculus Q63ZW7
Y2H
9647694
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05804 GRIN2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grin2a NCBI NCBI:2903
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